FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2835715288> ?p ?o ?g. }

• W2835715288 endingPage "2091" @default.
• W2835715288 startingPage "2073" @default.
• W2835715288 abstract "PrPSc is an infectious and disease-specific conformer of the prion protein, which accumulation in the CNS underlies the pathology of prion diseases. PrPSc replicates by binding to the cellular conformer of the prion protein (PrPC) expressed by host cells and rendering its secondary structure a likeness of itself. PrPC is a plasma membrane anchored protein, which constitutively recirculates between the cell surface and the endocytic compartment. Since PrPSc engages PrPC along this trafficking pathway, its replication process is often referred to as recycling propagation. Certain monoclonal antibodies (mAbs) directed against prion protein can abrogate the presence of PrPSc from prion-infected cells. However, the precise mechanism(s) underlying their therapeutic propensities remains obscure. Using N2A murine neuroblastoma cell line stably infected with 22L mouse-adapted scrapie strain (N2A/22L), we investigated here the modus operandi of the 6D11 clone, which was raised against the PrPSc conformer and has been shown to permanently clear prion-infected cells from PrPSc presence. We determined that 6D11 mAb engages and sequesters PrPC and PrPSc at the cell surface. PrPC/6D11 and PrPSc/6D11 complexes are then endocytosed from the plasma membrane and are directed to lysosomes, therefore precluding recirculation of nascent PrPSc back to the cell surface. Targeting PrPSc by 6D11 mAb to the lysosomal compartment facilitates its proteolysis and eventually shifts the balance between PrPSc formation and degradation. Ongoing translation of PrPC allows maintaining the steady-state level of prion protein within the cells, which was not depleted under 6D11 mAb treatment. Our findings demonstrate that through disrupting recycling propagation of PrPSc and promoting its degradation, 6D11 mAb restores cellular proteostasis of prion protein." @default.
• W2835715288 created "2018-07-19" @default.
• W2835715288 creator A5038956310 @default.
• W2835715288 creator A5056275157 @default.
• W2835715288 creator A5070989951 @default.
• W2835715288 creator A5080321307 @default.
• W2835715288 creator A5080736290 @default.
• W2835715288 date "2018-07-09" @default.
• W2835715288 modified "2023-10-16" @default.
• W2835715288 title "Anti-prion Protein Antibody 6D11 Restores Cellular Proteostasis of Prion Protein Through Disrupting Recycling Propagation of PrPSc and Targeting PrPSc for Lysosomal Degradation" @default.
• W2835715288 cites W1501494207 @default.
• W2835715288 cites W1518703223 @default.
• W2835715288 cites W1565095563 @default.
• W2835715288 cites W15745146 @default.
• W2835715288 cites W1836242379 @default.
• W2835715288 cites W1893748374 @default.
• W2835715288 cites W1968558040 @default.
• W2835715288 cites W1978525961 @default.
• W2835715288 cites W1984973536 @default.
• W2835715288 cites W1992675300 @default.
• W2835715288 cites W1993820504 @default.
• W2835715288 cites W1994370651 @default.
• W2835715288 cites W2000966016 @default.
• W2835715288 cites W2002497988 @default.
• W2835715288 cites W2005363319 @default.
• W2835715288 cites W2007093034 @default.
• W2835715288 cites W2015662447 @default.
• W2835715288 cites W2031606527 @default.
• W2835715288 cites W2038142248 @default.
• W2835715288 cites W2039730896 @default.
• W2835715288 cites W2039879202 @default.
• W2835715288 cites W2043721114 @default.
• W2835715288 cites W2057073891 @default.
• W2835715288 cites W2061603851 @default.
• W2835715288 cites W2063062799 @default.
• W2835715288 cites W2063553621 @default.
• W2835715288 cites W2063559185 @default.
• W2835715288 cites W2069479748 @default.
• W2835715288 cites W2071324391 @default.
• W2835715288 cites W2085805177 @default.
• W2835715288 cites W2090339308 @default.
• W2835715288 cites W2091564181 @default.
• W2835715288 cites W2094478367 @default.
• W2835715288 cites W2098403752 @default.
• W2835715288 cites W2112140556 @default.
• W2835715288 cites W2113792335 @default.
• W2835715288 cites W2114496280 @default.
• W2835715288 cites W2115896942 @default.
• W2835715288 cites W2120014936 @default.
• W2835715288 cites W2125638651 @default.
• W2835715288 cites W2125782175 @default.
• W2835715288 cites W2130110018 @default.
• W2835715288 cites W2131082569 @default.
• W2835715288 cites W2137782260 @default.
• W2835715288 cites W2146983291 @default.
• W2835715288 cites W2147703009 @default.
• W2835715288 cites W2152059298 @default.
• W2835715288 cites W2152477469 @default.
• W2835715288 cites W2152958744 @default.
• W2835715288 cites W2154713296 @default.
• W2835715288 cites W2155858875 @default.
• W2835715288 cites W2164627569 @default.
• W2835715288 cites W2167503783 @default.
• W2835715288 cites W2327641970 @default.
• W2835715288 cites W2510806376 @default.
• W2835715288 cites W2559946394 @default.
• W2835715288 cites W2574044606 @default.
• W2835715288 cites W2767917466 @default.
• W2835715288 cites W2769118369 @default.
• W2835715288 cites W2774323047 @default.
• W2835715288 cites W4245253137 @default.
• W2835715288 cites W4252808594 @default.
• W2835715288 doi "https://doi.org/10.1007/s12035-018-1208-4" @default.
• W2835715288 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6326903" @default.
• W2835715288 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29987703" @default.
• W2835715288 hasPublicationYear "2018" @default.
• W2835715288 type Work @default.
• W2835715288 sameAs 2835715288 @default.
• W2835715288 citedByCount "13" @default.
• W2835715288 countsByYear W28357152882019 @default.
• W2835715288 countsByYear W28357152882020 @default.
• W2835715288 countsByYear W28357152882021 @default.
• W2835715288 countsByYear W28357152882022 @default.
• W2835715288 crossrefType "journal-article" @default.
• W2835715288 hasAuthorship W2835715288A5038956310 @default.
• W2835715288 hasAuthorship W2835715288A5056275157 @default.
• W2835715288 hasAuthorship W2835715288A5070989951 @default.
• W2835715288 hasAuthorship W2835715288A5080321307 @default.
• W2835715288 hasAuthorship W2835715288A5080736290 @default.
• W2835715288 hasBestOaLocation W28357152882 @default.
• W2835715288 hasConcept C102747710 @default.
• W2835715288 hasConcept C136238340 @default.
• W2835715288 hasConcept C142724271 @default.
• W2835715288 hasConcept C1491633281 @default.
• W2835715288 hasConcept C159654299 @default.
• W2835715288 hasConcept C181199279 @default.
• W2835715288 hasConcept C185592680 @default.
• W2835715288 hasConcept C203014093 @default.

• next