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- W2836080 abstract "The cholinergic system of the brain is involved in the regulation of attention and higher-order cognitive processing. Alterations of the cholinergic system have been described in aging and especially in Alzheimer’s disease (AD). Studies using positron emission tomography (PET) and functional magnetic resonance imaging reported reduced prefrontal metabolism and perfusion with maintained or even increased task performance during cholinergic stimulation in both young and older healthy people. Similar effects in patients with AD suggest that the cholinergic system remains responsive even in mild to moderate stages of the disease. Using specific ligands to muscarinic and nicotinic acetylcholine receptors and cholinesterase, PET studies found alterations of cholinergic neurotransmission in AD. Recently, structural magnetic resonance imaging has been employed to determine the morphological integrity of the basal forebrain cholinergic nuclei in vivo. This article summarizes the methodological background and the key findings derived from neuroimaging studies directed to the analysis of the cholinergic system and indicates potential lines of future research." @default.
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- W2836080 date "2009-01-01" @default.
- W2836080 modified "2023-09-24" @default.
- W2836080 title "Cholinergic System Imaging in the Healthy Aging Process and Alzheimer Disease" @default.
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- W2836080 doi "https://doi.org/10.1016/b978-008045046-9.02041-6" @default.
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