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- W2836698146 abstract "The kinetoplastida and their close relatives are unicellular organisms prevalent within the biosphere and important for significant impacts on global health, economy and ecosystems. They are, under most models, an early branching lineage. Individual species adapted to highly diverse environments by adopting complex life styles; parasitic species can infect a wide range of eukaryotic hosts, while many relatives are free‐living and some autotrophic from acquiring a plastid for photosynthesis. Adaptation is especially evident in the evolution of kinetoplastid cell surface architecture and is supported by endomembrane trafficking and serves as a platform for interaction with its environment. Here we summarize and discuss recent genomic and experimental studies of the protein trafficking system in kinetoplastids, with focus on the composition and function of the surface as well as mechanisms for constructing, maintaining and regulating the cell surface proteome. We hope this provides a broad view of how protein trafficking contributes to the intricate and dynamic host‐parasite interfaces that are critical for successful environmental adaptation of this highly important lineage." @default.
- W2836698146 created "2018-07-19" @default.
- W2836698146 creator A5054418515 @default.
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- W2836698146 creator A5065802663 @default.
- W2836698146 creator A5067004044 @default.
- W2836698146 creator A5073502995 @default.
- W2836698146 date "2018-07-24" @default.
- W2836698146 modified "2023-10-14" @default.
- W2836698146 title "Evolution of protein trafficking in kinetoplastid parasites: Complexity and pathogenesis" @default.
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- W2836698146 doi "https://doi.org/10.1111/tra.12601" @default.
- W2836698146 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29974581" @default.
- W2836698146 hasPublicationYear "2018" @default.
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