FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2836966611> ?p ?o ?g. }

• W2836966611 endingPage "100" @default.
• W2836966611 startingPage "95" @default.
• W2836966611 abstract "The effect of three newly developed bispyridinium non-oxime compounds (MB408, MB442, and MB444) on the therapeutic efficacy of a standard antidotal treatment (atropine in combination with the oxime HI-6 or obidoxime) of acute poisoning by two nerve agents (sarin and cyclosarin) in mice was studied. The therapeutic efficacy of atropine in combination with an oxime with or without one of the bispyridinium non-oximes was evaluated by determination of the 24 h LD50 values of the nerve agents studied and by measurement of the survival time after supralethal poisoning. Addition of all tested non-oximes increased the therapeutic efficacy of atropine in combination with an oxime against sarin poisoning; however, the differences were not significant. The non-oximes also positively influenced the number of surviving mice 6 h after supralethal poisoning with sarin. In the case of cyclosarin, they were also slightly beneficial in the treatment of acute poisoning. The higher dose of MB444 was able to significantly increase the therapeutic efficacy of standard antidotal treatment of poisoning with cyclosarin. The benefit of each bispyridinium non-oxime compound itself was obviously dose-dependent. In summary, the addition of MB compounds to the standard antidotal treatment of acute nerve agent poisoning was beneficial for the antidotal treatment of sarin or cyclosarin poisoning, although their benefit at 24 h after poisoning was not significant, with the exception of the higher dose of MB444 against cyclosarin." @default.
• W2836966611 created "2018-07-19" @default.
• W2836966611 creator A5007888170 @default.
• W2836966611 creator A5022800349 @default.
• W2836966611 creator A5033357190 @default.
• W2836966611 creator A5057527075 @default.
• W2836966611 creator A5071643756 @default.
• W2836966611 creator A5073883365 @default.
• W2836966611 date "2018-09-01" @default.
• W2836966611 modified "2023-10-18" @default.
• W2836966611 title "Some benefit from non-oximes MB408, MB442 and MB444 in combination with the oximes HI-6 or obidoxime and atropine in antidoting sarin or cyclosarin poisoned mice" @default.
• W2836966611 cites W1146106225 @default.
• W2836966611 cites W1146349298 @default.
• W2836966611 cites W1707439038 @default.
• W2836966611 cites W1969407691 @default.
• W2836966611 cites W1973198019 @default.
• W2836966611 cites W1975988365 @default.
• W2836966611 cites W1977215955 @default.
• W2836966611 cites W1989488731 @default.
• W2836966611 cites W2043476788 @default.
• W2836966611 cites W2054502621 @default.
• W2836966611 cites W2059122366 @default.
• W2836966611 cites W2070556630 @default.
• W2836966611 cites W2072591839 @default.
• W2836966611 cites W2079338540 @default.
• W2836966611 cites W2085201812 @default.
• W2836966611 cites W2085845997 @default.
• W2836966611 cites W2085907924 @default.
• W2836966611 cites W2087329467 @default.
• W2836966611 cites W2095384268 @default.
• W2836966611 cites W2096430284 @default.
• W2836966611 cites W2101501097 @default.
• W2836966611 cites W2124012440 @default.
• W2836966611 cites W2138702835 @default.
• W2836966611 cites W2166297549 @default.
• W2836966611 cites W2336712643 @default.
• W2836966611 cites W2767641390 @default.
• W2836966611 cites W2767954880 @default.
• W2836966611 cites W2950339369 @default.
• W2836966611 cites W4245073240 @default.
• W2836966611 doi "https://doi.org/10.1016/j.tox.2018.07.008" @default.
• W2836966611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30005893" @default.
• W2836966611 hasPublicationYear "2018" @default.
• W2836966611 type Work @default.
• W2836966611 sameAs 2836966611 @default.
• W2836966611 citedByCount "6" @default.
• W2836966611 countsByYear W28369666112020 @default.
• W2836966611 countsByYear W28369666112021 @default.
• W2836966611 countsByYear W28369666112022 @default.
• W2836966611 crossrefType "journal-article" @default.
• W2836966611 hasAuthorship W2836966611A5007888170 @default.
• W2836966611 hasAuthorship W2836966611A5022800349 @default.
• W2836966611 hasAuthorship W2836966611A5033357190 @default.
• W2836966611 hasAuthorship W2836966611A5057527075 @default.
• W2836966611 hasAuthorship W2836966611A5071643756 @default.
• W2836966611 hasAuthorship W2836966611A5073883365 @default.
• W2836966611 hasConcept C181199279 @default.
• W2836966611 hasConcept C185592680 @default.
• W2836966611 hasConcept C2775859210 @default.
• W2836966611 hasConcept C2776130705 @default.
• W2836966611 hasConcept C2776327929 @default.
• W2836966611 hasConcept C2778706303 @default.
• W2836966611 hasConcept C2778816929 @default.
• W2836966611 hasConcept C2779648554 @default.
• W2836966611 hasConcept C2780266723 @default.
• W2836966611 hasConcept C2780292010 @default.
• W2836966611 hasConcept C42219234 @default.
• W2836966611 hasConcept C55493867 @default.
• W2836966611 hasConcept C71924100 @default.
• W2836966611 hasConcept C98274493 @default.
• W2836966611 hasConceptScore W2836966611C181199279 @default.
• W2836966611 hasConceptScore W2836966611C185592680 @default.
• W2836966611 hasConceptScore W2836966611C2775859210 @default.
• W2836966611 hasConceptScore W2836966611C2776130705 @default.
• W2836966611 hasConceptScore W2836966611C2776327929 @default.
• W2836966611 hasConceptScore W2836966611C2778706303 @default.
• W2836966611 hasConceptScore W2836966611C2778816929 @default.
• W2836966611 hasConceptScore W2836966611C2779648554 @default.
• W2836966611 hasConceptScore W2836966611C2780266723 @default.
• W2836966611 hasConceptScore W2836966611C2780292010 @default.
• W2836966611 hasConceptScore W2836966611C42219234 @default.
• W2836966611 hasConceptScore W2836966611C55493867 @default.
• W2836966611 hasConceptScore W2836966611C71924100 @default.
• W2836966611 hasConceptScore W2836966611C98274493 @default.
• W2836966611 hasLocation W28369666111 @default.
• W2836966611 hasLocation W28369666112 @default.
• W2836966611 hasOpenAccess W2836966611 @default.
• W2836966611 hasPrimaryLocation W28369666111 @default.
• W2836966611 hasRelatedWork W2002381241 @default.
• W2836966611 hasRelatedWork W2065957780 @default.
• W2836966611 hasRelatedWork W2091417037 @default.
• W2836966611 hasRelatedWork W2134557318 @default.
• W2836966611 hasRelatedWork W2138702835 @default.
• W2836966611 hasRelatedWork W2140514241 @default.
• W2836966611 hasRelatedWork W2143984301 @default.
• W2836966611 hasRelatedWork W2336712643 @default.
• W2836966611 hasRelatedWork W2382198582 @default.
• W2836966611 hasRelatedWork W4224212594 @default.

• next