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- W2837611462 abstract "Obese patients have increased leptin production and selective resistance to its central anti-adipogenic effects, yet its pro-inflammatory immunostimulating effects persist.In a group of 70 patients who underwent primary kidney transplantation (KT) we examined adiponectin and leptin levels at the time of KT and 6 months post-transplantation. Patients with diabetes mellitus type 1 or type 2 at the time of KT were excluded from the study.We found that leptin levels significantly increased during the post-transplant period (P = 0.0065). Overall, leptin levels were positively correlated with the level of triacylglycerols, post-transplant diabetes mellitus (PTDM) development and acute rejection (AR). We discovered that, in particular, high leptin levels were associated with AR [OR 2.1273; 95% CI 1.0130-4.4671 (P = 0.0461)] and PTDM development [OR 7.200; 95% CI 1.0310-50.2836 (P = 0.0465)], whereas, low adiponectin levels represent a risk factor for the development of insulin resistance [HR 38.6135; 95% CI 13.3844-67.7699 (P < 0.0001)] and obesity [HR 3.0821; 95% CI 0.8700-10.9192 (P = 0.0053)].We found that a high serum concentration of leptin before KT is associated with both PTDM development and AR and merits further investigation in relation to KT." @default.
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- W2837611462 date "2018-09-01" @default.
- W2837611462 modified "2023-10-17" @default.
- W2837611462 title "Leptin – A new marker for development of post-transplant diabetes mellitus?" @default.
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- W2837611462 doi "https://doi.org/10.1016/j.jdiacomp.2018.07.002" @default.
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