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- W28394549 abstract "Autoimmune myasthenia gravis is the prototypic autoimmune disease. The disease is clinically heterogeneous with regard to demographics, clinical presentation, severity, associated diseases, thymic pathology, and response to therapy. In recent years, it has become clear that there are immunologic and immunogenetic factors that partially explain this clinical heterogeneity. In addition to immune responses directed against the muscle nicotinic acetylcholine receptor, antibodies have now been detected against muscle-specific kinase, lipoprotein-related protein 4, and most recently agrin. The commonality is that antibodies against all of these molecules lead to various changes in the postsynaptic endplate region of muscle leading to failure of normal neuromuscular transmission." @default.
- W28394549 created "2016-06-24" @default.
- W28394549 creator A5009994219 @default.
- W28394549 date "2014-01-01" @default.
- W28394549 modified "2023-09-23" @default.
- W28394549 title "Myasthenia Gravis, Immunology of" @default.
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- W28394549 doi "https://doi.org/10.1016/b978-0-12-385157-4.00185-8" @default.
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