Matches in SemOpenAlex for { <https://semopenalex.org/work/W28402833> ?p ?o ?g. }
- W28402833 endingPage "158" @default.
- W28402833 startingPage "139" @default.
- W28402833 abstract "Dendritic cells (DCs) play a key role in the orchestration of immune reactions. Manipulation of DC function through genetic manipulation for vaccine development provides a multitude of applications for active immunotherapy of cancer and chronic infections. Several laboratories have shown that lentiviral vectors (LVs) are efficient and consistent tools for ex vivo gene manipulation of DCs and their precursors. LVs integrate in the genome of target cells resulting in persistent and stable transgene expression, and gene delivery does not result in cytostatic or nonspecific adverse immunomodulatory reactions. Mouse, macaque, and human DCs are efficiently transduced with LVs, allowing preclinical vaccination studies to be gradually implemented into clinical trials. This chapter describes HIV-1-derived LV transduction used for ex vivo gene delivery of marking genes, antigens, and immunomodulatory molecules into mouse and human hematopoietic precursors and DCs. With the perspective of bioengineering DCs from the inside-out, we also describe a one-hit LV transduction method for constitutive expression of GM-CSF and IL-4 genes, which allows self-differentiation of mouse and human hematopoietic precursor cells into highly viable and potent DCs." @default.
- W28402833 created "2016-06-24" @default.
- W28402833 creator A5007570262 @default.
- W28402833 date "2009-01-01" @default.
- W28402833 modified "2023-10-05" @default.
- W28402833 title "Lentiviral Vector-Mediated Genetic Programming of Mouse and Human Dendritic Cells" @default.
- W28402833 cites W1544190956 @default.
- W28402833 cites W1566969252 @default.
- W28402833 cites W1661544713 @default.
- W28402833 cites W1942388374 @default.
- W28402833 cites W1967863944 @default.
- W28402833 cites W1972576862 @default.
- W28402833 cites W1972758309 @default.
- W28402833 cites W1974001377 @default.
- W28402833 cites W1980402892 @default.
- W28402833 cites W2006376260 @default.
- W28402833 cites W2009985995 @default.
- W28402833 cites W2011277077 @default.
- W28402833 cites W2011847596 @default.
- W28402833 cites W2012272429 @default.
- W28402833 cites W2016844928 @default.
- W28402833 cites W2020393110 @default.
- W28402833 cites W2030699641 @default.
- W28402833 cites W2032173363 @default.
- W28402833 cites W2034099314 @default.
- W28402833 cites W2038219160 @default.
- W28402833 cites W2054512182 @default.
- W28402833 cites W2058205936 @default.
- W28402833 cites W2075487318 @default.
- W28402833 cites W2075932312 @default.
- W28402833 cites W2078169017 @default.
- W28402833 cites W2080420690 @default.
- W28402833 cites W2080729676 @default.
- W28402833 cites W2081152691 @default.
- W28402833 cites W2083164537 @default.
- W28402833 cites W2087057703 @default.
- W28402833 cites W2087362541 @default.
- W28402833 cites W2099306137 @default.
- W28402833 cites W2114621817 @default.
- W28402833 cites W2122545802 @default.
- W28402833 cites W2124993705 @default.
- W28402833 cites W2131761283 @default.
- W28402833 cites W2140944306 @default.
- W28402833 cites W2147138386 @default.
- W28402833 cites W2154853638 @default.
- W28402833 cites W2160641725 @default.
- W28402833 cites W2172658766 @default.
- W28402833 cites W2180045011 @default.
- W28402833 cites W2980792274 @default.
- W28402833 doi "https://doi.org/10.1007/978-1-59745-409-4_11" @default.
- W28402833 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19110625" @default.
- W28402833 hasPublicationYear "2009" @default.
- W28402833 type Work @default.
- W28402833 sameAs 28402833 @default.
- W28402833 citedByCount "17" @default.
- W28402833 countsByYear W284028332012 @default.
- W28402833 countsByYear W284028332013 @default.
- W28402833 countsByYear W284028332014 @default.
- W28402833 countsByYear W284028332015 @default.
- W28402833 countsByYear W284028332017 @default.
- W28402833 countsByYear W284028332018 @default.
- W28402833 countsByYear W284028332022 @default.
- W28402833 crossrefType "book-chapter" @default.
- W28402833 hasAuthorship W28402833A5007570262 @default.
- W28402833 hasConcept C102230213 @default.
- W28402833 hasConcept C104317684 @default.
- W28402833 hasConcept C109159458 @default.
- W28402833 hasConcept C111599444 @default.
- W28402833 hasConcept C135983454 @default.
- W28402833 hasConcept C15152581 @default.
- W28402833 hasConcept C159047783 @default.
- W28402833 hasConcept C203014093 @default.
- W28402833 hasConcept C207001950 @default.
- W28402833 hasConcept C26291073 @default.
- W28402833 hasConcept C2777701055 @default.
- W28402833 hasConcept C2778170410 @default.
- W28402833 hasConcept C2780674031 @default.
- W28402833 hasConcept C28328180 @default.
- W28402833 hasConcept C32470452 @default.
- W28402833 hasConcept C40767141 @default.
- W28402833 hasConcept C54355233 @default.
- W28402833 hasConcept C55493867 @default.
- W28402833 hasConcept C70721500 @default.
- W28402833 hasConcept C86803240 @default.
- W28402833 hasConcept C8891405 @default.
- W28402833 hasConcept C95444343 @default.
- W28402833 hasConceptScore W28402833C102230213 @default.
- W28402833 hasConceptScore W28402833C104317684 @default.
- W28402833 hasConceptScore W28402833C109159458 @default.
- W28402833 hasConceptScore W28402833C111599444 @default.
- W28402833 hasConceptScore W28402833C135983454 @default.
- W28402833 hasConceptScore W28402833C15152581 @default.
- W28402833 hasConceptScore W28402833C159047783 @default.
- W28402833 hasConceptScore W28402833C203014093 @default.
- W28402833 hasConceptScore W28402833C207001950 @default.
- W28402833 hasConceptScore W28402833C26291073 @default.
- W28402833 hasConceptScore W28402833C2777701055 @default.
- W28402833 hasConceptScore W28402833C2778170410 @default.