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- W2840694248 abstract "Abstract Sea cucumbers produce saponins as a chemical defense mechanism, however their cells can tolerate the cytotoxic nature of these chemicals. To elucidate the molecular mechanisms behind this tolerance a suite of complementary biophysical tools was used, firstly using liposomes for in vitro techniques then using in silico approaches for a molecular-level insight. The holothuroid saponin Frondoside A, caused significantly less permeabilization in liposomes containing a Δ 7 holothuroid sterol than those containing cholesterol and resulted in endothermic interactions versus exothermic interactions with cholesterol containing liposomes. Lipid phases simulations revealed that Frondoside A has an agglomerating effect on cholesterol domains, however, induced small irregular Δ 7 sterol clusters. Our results suggest that the structural peculiarities of holothuroid sterols provide sea cucumbers with a mechanism to mitigate the sterol-agglomerating effect of saponins, and therefore to protect their cells from the cytotoxicity of the saponins they produce." @default.
- W2840694248 created "2018-07-19" @default.
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- W2840694248 date "2018-07-18" @default.
- W2840694248 modified "2023-10-13" @default.
- W2840694248 title "How different sterols contribute to saponin tolerant plasma membranes in sea cucumbers" @default.
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- W2840694248 doi "https://doi.org/10.1038/s41598-018-29223-x" @default.
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