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- W2843670892 abstract "Ketamine is a well-known general anesthetic that inhibits cerebral NMDA receptors. Norketamine is a major circulating metabolite of this drug. A nasal spray formulation of esketamine, the S enantiomer of ketamine, is under development for the management of treatment-resistant depression. To assess the pharmacokinetic properties, C-14 labeled ketamine and norketamine were prepared separately from commercially available [14C]CuCN through a five-step sequence with the C-14 label at the quaternary carbon of the cyclohexyl ring. Chiral resolution of [14C]ketamine and chiral column separation of [14C]norketamine resolved/separated the (S)-enantiomers from (R)-enantiomers." @default.
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- W2843670892 date "2018-07-29" @default.
- W2843670892 modified "2023-09-27" @default.
- W2843670892 title "Synthesis of carbon-14 labeled ketamine and norketamine" @default.
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- W2843670892 doi "https://doi.org/10.1002/jlcr.3669" @default.
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