Matches in SemOpenAlex for { <https://semopenalex.org/work/W284448648> ?p ?o ?g. }
- W284448648 abstract "Abstract Microvascular complications (neuropathy, nephropathy, and retinopathy) are very common in patients with type 2 diabetes (T2D) and contribute significantly to the morbidity and mortality of this condition. Hence, preventing the development or slowing the progression of these complications is a major aim of treatment in patients with T2D. However, despite the beneficial impact of intensive metabolic control, these complications remain very common. Obstructive sleep apnea (OSA) and T2D share a major risk factor, which is obesity; therefore, it is not surprising that these two conditions often co-exist. OSA and hyperglycemia share common molecular consequences, such as increased oxidative and nitrosative stress, protein kinase C activation, increased advance glycation end-product, and increased inflammation—all of which can result in vascular disease. Hence, it is plausible that OSA might contribute to the development and progression of microvascular complications in patients with T2D. Several cross-sectional studies have shown that diabetic nephropathy, neuropathy, and sight-threatening retinopathy are more common in patients with T2D and OSA than T2D only. More importantly, early longitudinal studies are suggestive that OSA results in the development of nephropathy and retinopathy in patients with T2D and that continuous positive airway pressure treatment might slow the development and progression of these complications. This area of research is still in its infancy, so more longitudinal and interventional studies are needed to determine the role of OSA and the impact of its treatment on the development and progression of microvascular complications in patients with T2D. Interestingly, early data from cross-sectional studies in patients with type 1 diabetes suggest a similar relationship between OSA and microvascular complications as that observed in patients with T2D." @default.
- W284448648 created "2016-06-24" @default.
- W284448648 creator A5025948772 @default.
- W284448648 creator A5090743194 @default.
- W284448648 date "2015-01-01" @default.
- W284448648 modified "2023-09-24" @default.
- W284448648 title "Obstructive Sleep Apnea and Diabetic Microvascular Complications" @default.
- W284448648 cites W1480771192 @default.
- W284448648 cites W151429262 @default.
- W284448648 cites W152234727 @default.
- W284448648 cites W1529592271 @default.
- W284448648 cites W1574286735 @default.
- W284448648 cites W1576143649 @default.
- W284448648 cites W1578810619 @default.
- W284448648 cites W1604056296 @default.
- W284448648 cites W1676536 @default.
- W284448648 cites W1719236872 @default.
- W284448648 cites W1755484345 @default.
- W284448648 cites W1928910419 @default.
- W284448648 cites W1932654578 @default.
- W284448648 cites W1965060213 @default.
- W284448648 cites W1966419887 @default.
- W284448648 cites W1967637427 @default.
- W284448648 cites W1967904505 @default.
- W284448648 cites W1969865402 @default.
- W284448648 cites W1973129979 @default.
- W284448648 cites W1977068381 @default.
- W284448648 cites W1977325333 @default.
- W284448648 cites W1977620104 @default.
- W284448648 cites W1980011437 @default.
- W284448648 cites W1982590077 @default.
- W284448648 cites W1983419371 @default.
- W284448648 cites W1984155065 @default.
- W284448648 cites W1984678806 @default.
- W284448648 cites W1985879298 @default.
- W284448648 cites W1988499887 @default.
- W284448648 cites W1991264623 @default.
- W284448648 cites W1991376073 @default.
- W284448648 cites W1995141700 @default.
- W284448648 cites W1996478420 @default.
- W284448648 cites W1996631823 @default.
- W284448648 cites W1997274278 @default.
- W284448648 cites W1997441748 @default.
- W284448648 cites W1999499773 @default.
- W284448648 cites W2001826110 @default.
- W284448648 cites W2002041877 @default.
- W284448648 cites W2002439105 @default.
- W284448648 cites W2002917636 @default.
- W284448648 cites W2007616848 @default.
- W284448648 cites W2009254187 @default.
- W284448648 cites W2009340697 @default.
- W284448648 cites W2009402354 @default.
- W284448648 cites W2009896907 @default.
- W284448648 cites W2013691124 @default.
- W284448648 cites W2017038002 @default.
- W284448648 cites W2019378652 @default.
- W284448648 cites W2021003272 @default.
- W284448648 cites W2024315099 @default.
- W284448648 cites W2025232426 @default.
- W284448648 cites W2025958954 @default.
- W284448648 cites W2026447046 @default.
- W284448648 cites W2027259499 @default.
- W284448648 cites W2034730235 @default.
- W284448648 cites W2034961610 @default.
- W284448648 cites W2036579970 @default.
- W284448648 cites W2038512402 @default.
- W284448648 cites W2038526887 @default.
- W284448648 cites W2038574779 @default.
- W284448648 cites W2038767124 @default.
- W284448648 cites W2038961236 @default.
- W284448648 cites W2041164592 @default.
- W284448648 cites W2043246888 @default.
- W284448648 cites W2044437167 @default.
- W284448648 cites W2045018039 @default.
- W284448648 cites W2046299960 @default.
- W284448648 cites W2051233403 @default.
- W284448648 cites W2052348843 @default.
- W284448648 cites W2052415197 @default.
- W284448648 cites W2052897592 @default.
- W284448648 cites W2054085768 @default.
- W284448648 cites W2054593321 @default.
- W284448648 cites W2054631468 @default.
- W284448648 cites W2054681721 @default.
- W284448648 cites W2056732650 @default.
- W284448648 cites W2057543584 @default.
- W284448648 cites W2059689055 @default.
- W284448648 cites W2066290187 @default.
- W284448648 cites W2068930966 @default.
- W284448648 cites W2075459286 @default.
- W284448648 cites W2078669850 @default.
- W284448648 cites W2082724449 @default.
- W284448648 cites W2083146145 @default.
- W284448648 cites W2083911580 @default.
- W284448648 cites W2084292135 @default.
- W284448648 cites W2085698266 @default.
- W284448648 cites W2088119628 @default.
- W284448648 cites W2090304978 @default.
- W284448648 cites W2091933728 @default.
- W284448648 cites W2092601978 @default.
- W284448648 cites W2097541024 @default.