FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2844517131> ?p ?o ?g. }

• W2844517131 endingPage "183" @default.
• W2844517131 startingPage "175" @default.
• W2844517131 abstract "Abstract Introduction: Past trials of buprenorphine (BUP) in the treatment of major depressive disorder (MDD) have displayed favorable results, although its clinical utility was limited by the risk of abuse or physical dependence. By combining BUP with samidorphan (SAM), the euphoric high is negated by an opposing mechanism, which theoretically reduces addictive-like properties while allowing the antidepressant properties to remain. As such, the objective of this article is to analyze the results of BUP/SAM premarketing clinical trials as adjunctive treatment for treatment-resistant MDD. Methods: A comprehensive PubMed/MEDLINE search was conducted through November 9, 2017, using the following search terms: depression, samidorphan, buprenorphine, ALKS-5461. Additional data were obtained from Clinicaltrials.gov and resources included in the present study. All English-language clinical trials evaluating the combination of BUP/SAM in the treatment of MDD were included. Results: A few premarketing studies have evaluated the efficacy and safety of BUP/SAM combination as adjunctive treatment in patients with treatment-resistant MDD. The FORWARD-1 through FORWARD-5 trials concluded (1) the most effective dosing ratio of BUP/SAM to reduce abuse potential was 1:1; (2) statistically significant changes in scores from baseline on the Montgomery-Asberg Depression Rating Scale were noted for the 2 mg/2 mg dose compared with placebo; and (3) the most commonly reported adverse effects were nausea, dizziness, and fatigue. Discussion: Buprenorphine/samidorphan has shown favorable results for efficacy and tolerability in premarketing studies evaluating its use as adjunctive therapy for treatment-resistant MDD. Its novel mechanism targeting the opioid pathway may serve as a promising antidepressant devoid of abuse potential." @default.
• W2844517131 created "2018-07-19" @default.
• W2844517131 creator A5016783795 @default.
• W2844517131 creator A5057519184 @default.
• W2844517131 creator A5076090169 @default.
• W2844517131 date "2018-07-01" @default.
• W2844517131 modified "2023-10-18" @default.
• W2844517131 title "Kappa opioid receptor antagonism: Are opioids the answer for treatment resistant depression?" @default.
• W2844517131 cites W1484409320 @default.
• W2844517131 cites W1653656108 @default.
• W2844517131 cites W1941293036 @default.
• W2844517131 cites W1972357973 @default.
• W2844517131 cites W1994125953 @default.
• W2844517131 cites W2007376383 @default.
• W2844517131 cites W2009220908 @default.
• W2844517131 cites W2010654991 @default.
• W2844517131 cites W2013358247 @default.
• W2844517131 cites W2035421865 @default.
• W2844517131 cites W2053183951 @default.
• W2844517131 cites W2053472601 @default.
• W2844517131 cites W2054092950 @default.
• W2844517131 cites W2054849655 @default.
• W2844517131 cites W2063621859 @default.
• W2844517131 cites W2070828096 @default.
• W2844517131 cites W2073658789 @default.
• W2844517131 cites W2086769768 @default.
• W2844517131 cites W2101525777 @default.
• W2844517131 cites W2132324173 @default.
• W2844517131 cites W2147147339 @default.
• W2844517131 cites W2149402043 @default.
• W2844517131 cites W2159202946 @default.
• W2844517131 cites W2165487960 @default.
• W2844517131 cites W2171367696 @default.
• W2844517131 cites W2269913603 @default.
• W2844517131 cites W2324466941 @default.
• W2844517131 cites W2402044500 @default.
• W2844517131 doi "https://doi.org/10.9740/mhc.2018.07.175" @default.
• W2844517131 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6063454" @default.
• W2844517131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30155392" @default.
• W2844517131 hasPublicationYear "2018" @default.
• W2844517131 type Work @default.
• W2844517131 sameAs 2844517131 @default.
• W2844517131 citedByCount "14" @default.
• W2844517131 countsByYear W28445171312019 @default.
• W2844517131 countsByYear W28445171312020 @default.
• W2844517131 countsByYear W28445171312021 @default.
• W2844517131 countsByYear W28445171312022 @default.
• W2844517131 countsByYear W28445171312023 @default.
• W2844517131 crossrefType "journal-article" @default.
• W2844517131 hasAuthorship W2844517131A5016783795 @default.
• W2844517131 hasAuthorship W2844517131A5057519184 @default.
• W2844517131 hasAuthorship W2844517131A5076090169 @default.
• W2844517131 hasBestOaLocation W28445171311 @default.
• W2844517131 hasConcept C118552586 @default.
• W2844517131 hasConcept C126322002 @default.
• W2844517131 hasConcept C142724271 @default.
• W2844517131 hasConcept C170493617 @default.
• W2844517131 hasConcept C197934379 @default.
• W2844517131 hasConcept C204787440 @default.
• W2844517131 hasConcept C27081682 @default.
• W2844517131 hasConcept C2777288759 @default.
• W2844517131 hasConcept C2777342061 @default.
• W2844517131 hasConcept C2778375690 @default.
• W2844517131 hasConcept C2778949969 @default.
• W2844517131 hasConcept C2780051608 @default.
• W2844517131 hasConcept C2780733359 @default.
• W2844517131 hasConcept C2781063702 @default.
• W2844517131 hasConcept C535046627 @default.
• W2844517131 hasConcept C71924100 @default.
• W2844517131 hasConceptScore W2844517131C118552586 @default.
• W2844517131 hasConceptScore W2844517131C126322002 @default.
• W2844517131 hasConceptScore W2844517131C142724271 @default.
• W2844517131 hasConceptScore W2844517131C170493617 @default.
• W2844517131 hasConceptScore W2844517131C197934379 @default.
• W2844517131 hasConceptScore W2844517131C204787440 @default.
• W2844517131 hasConceptScore W2844517131C27081682 @default.
• W2844517131 hasConceptScore W2844517131C2777288759 @default.
• W2844517131 hasConceptScore W2844517131C2777342061 @default.
• W2844517131 hasConceptScore W2844517131C2778375690 @default.
• W2844517131 hasConceptScore W2844517131C2778949969 @default.
• W2844517131 hasConceptScore W2844517131C2780051608 @default.
• W2844517131 hasConceptScore W2844517131C2780733359 @default.
• W2844517131 hasConceptScore W2844517131C2781063702 @default.
• W2844517131 hasConceptScore W2844517131C535046627 @default.
• W2844517131 hasConceptScore W2844517131C71924100 @default.
• W2844517131 hasIssue "4" @default.
• W2844517131 hasLocation W28445171311 @default.
• W2844517131 hasLocation W28445171312 @default.
• W2844517131 hasLocation W28445171313 @default.
• W2844517131 hasLocation W28445171314 @default.
• W2844517131 hasLocation W28445171315 @default.
• W2844517131 hasOpenAccess W2844517131 @default.
• W2844517131 hasPrimaryLocation W28445171311 @default.
• W2844517131 hasRelatedWork W1966047811 @default.
• W2844517131 hasRelatedWork W2003042623 @default.
• W2844517131 hasRelatedWork W2005481147 @default.
• W2844517131 hasRelatedWork W202460821 @default.
• W2844517131 hasRelatedWork W2030348591 @default.

• next