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- W284506773 abstract "Publisher Summary This chapter examines the synthesis and posttranslational modification of retrovirus precursor polyproteins encoded by group specific antigen (gag) and envelope (env) genes. The structural properties of type-C RNA tumor viruses are synthesized as large precursor polyproteins—products of the gag and env genes. These polyproteins are accurately cleaved by proteolytic enzymes. Other posttranslational modification important for virus maturation and assembly are glycosylation and phosphorylation. In a study described in the chapter, these processes were studied in cells infected with Rausher murine leukemia virus using radiolabeled precursor in pulse chase experiments, immune precipitation with antibodies directed against specific antigenic determinants of virion component polypeptides, and sodium dodecyl sulfate-polyacryl-made gel electrophoresis. It is found that gag-gene encode proteins are processed from a common precursor by two divergent pathways. In addition env-gene encoded envelope protein p15E and glycoprotein gp70 arise from Pr70 by glycosylation and subsequent cleavage. Chemical cleavage of Pr65, Pr75, and gPr80 followed by peptide mapping demonstrated that all three polyproteins possess similar carboxyl-terminal regions whereas Pr75 and gPr80 are distinguished from Pr65 by a long amino-terminal leader sequence." @default.
- W284506773 created "2016-06-24" @default.
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- W284506773 date "1979-01-01" @default.
- W284506773 modified "2023-09-23" @default.
- W284506773 title "SYNTHESIS AND POST-TRANSLATIONAL MODIFICATION OF RETROVIRUS PRECURSOR POLYPROTEINS ENCODED BY gag AND env GENES" @default.
- W284506773 doi "https://doi.org/10.1016/b978-0-12-604450-8.50090-0" @default.
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