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- W2845852940 endingPage "2697" @default.
- W2845852940 startingPage "2686" @default.
- W2845852940 abstract "Blockade of the programmed death ligand 1 (PD-L1) and programmed cell death 1 (PD-1) receptor axis represents an effective form of cancer immunotherapy. Preclinical evidence initially suggested that gastric and gastroesophageal junction (GEJ) cancers are potentially immunotherapy-sensitive tumors. Early phase clinical trials have demonstrated promising antitumor activity with PD-1/PD-L1 blockade in advanced or metastatic gastric/GEJ cancer. Microsatellite instability (MSI) and PD-L1 expression have been shown to predict higher response to PD-1 inhibitors as highlighted by the recent approvals of pembrolizumab in treatment-refractory solid tumors with MSI status and the third-line or greater treatment of PD-L1 positive advanced gastric/GEJ cancers. However, predictive and prognostic biomarkers remain an ongoing need. In this review, we detail the preclinical evidence and early tissue biomarker analyses illustrating potential predictive biomarkers to PD-1/PD-L1 blockade in gastric/GEJ cancer. We also review the clinical development of PD-1/PD-L1 inhibitors in gastric/GEJ cancer and highlight several areas in need of future investigation in order to optimize the efficacy of PD-1/PD-L1 blockade in gastric/GEJ cancer." @default.
- W2845852940 created "2018-07-19" @default.
- W2845852940 creator A5009303158 @default.
- W2845852940 creator A5016986340 @default.
- W2845852940 creator A5071611972 @default.
- W2845852940 creator A5084571872 @default.
- W2845852940 date "2018-07-07" @default.
- W2845852940 modified "2023-10-10" @default.
- W2845852940 title "Advances in immuno-oncology biomarkers for gastroesophageal cancer: Programmed death ligand 1, microsatellite instability, and beyond" @default.
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- W2845852940 doi "https://doi.org/10.3748/wjg.v24.i25.2686" @default.
- W2845852940 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6034145" @default.
- W2845852940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29991874" @default.
- W2845852940 hasPublicationYear "2018" @default.
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