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- W28492984 endingPage "76" @default.
- W28492984 startingPage "57" @default.
- W28492984 abstract "Estrogens stimulate breast cancer growth and lifetime estrogen exposure is a risk factor for development of breast cancer (reviewed in (1)). Thus, it is desirable to block estrogen action in cancer treatment and prevention. Estrogens also exert positive effects upon overall health, including prevention of osteoporosis and reduced cardiovascular disease. Thus, it is also desirable to either supply estrogens, or mimic estrogen action, in hormone replacement therapy. The selective estrogen receptor modulators (SERMs) are synthetic compounds that block the growth of estrogen–dependent breast cancers and are showing promise as breast cancer preventatives (2). Remarkably, the SERMs also exhibit unique profiles of estrogenlike effects in other tissues, such as the uterotropic activity of tamoxifen and the ability of tamoxifen and raloxifene to arrest bone loss (reviewed in (2–4)). The SERMs can even exhibit novel activities that are not shared with estrogens (5–10). It may be possible to harness these mixed agonist/antagonist behaviors to develop new hormone replacement therapies that would simultaneously function as cancer drugs or cancer preventatives. Understanding the mechanisms that underlie these diverse SERM behaviors will be an important step towards this goal." @default.
- W28492984 created "2016-06-24" @default.
- W28492984 creator A5031784533 @default.
- W28492984 date "2002-01-01" @default.
- W28492984 modified "2023-09-24" @default.
- W28492984 title "SERM Modulation of Gene Expression" @default.
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