Matches in SemOpenAlex for { <https://semopenalex.org/work/W2849590047> ?p ?o ?g. }
- W2849590047 endingPage "3412" @default.
- W2849590047 startingPage "3402" @default.
- W2849590047 abstract "Myocardial infarction (MI) arising from obstruction of the coronary circulation engenders massive cardiomyocyte loss and replacement by non-contractile scar tissue, leading to pathological remodeling, dysfunction, and ultimately heart failure. This is presently a global health problem for which there is no effective cure. Following MI, the innate immune system directs the phagocytosis of dead cell debris in an effort to stimulate cell repopulation and tissue renewal. In the mammalian adult heart, however, the persistent influx of immune cells, coupled with the lack of an inherent regenerative capacity, results in cardiac fibrosis. Here, we reveal that stimulation of cardiac lymphangiogenesis with VEGF-C improves clearance of the acute inflammatory response after MI by trafficking immune cells to draining mediastinal lymph nodes (MLNs) in a process dependent on lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1). Deletion of Lyve1 in mice, preventing docking and transit of leukocytes through the lymphatic endothelium, results in exacerbation of chronic inflammation and long-term deterioration of cardiac function. Our findings support targeting of the lymphatic/immune cell axis as a therapeutic paradigm to promote immune modulation and heart repair." @default.
- W2849590047 created "2018-07-19" @default.
- W2849590047 creator A5015038317 @default.
- W2849590047 creator A5026650904 @default.
- W2849590047 creator A5026667794 @default.
- W2849590047 creator A5030823404 @default.
- W2849590047 creator A5038164428 @default.
- W2849590047 creator A5050716279 @default.
- W2849590047 creator A5062882861 @default.
- W2849590047 creator A5064842155 @default.
- W2849590047 creator A5071148454 @default.
- W2849590047 creator A5085888535 @default.
- W2849590047 creator A5086937841 @default.
- W2849590047 date "2018-07-09" @default.
- W2849590047 modified "2023-10-15" @default.
- W2849590047 title "The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction" @default.
- W2849590047 cites W1558779429 @default.
- W2849590047 cites W1568237782 @default.
- W2849590047 cites W1599795258 @default.
- W2849590047 cites W1935332540 @default.
- W2849590047 cites W1969038150 @default.
- W2849590047 cites W1971717482 @default.
- W2849590047 cites W1973404873 @default.
- W2849590047 cites W1978680347 @default.
- W2849590047 cites W1992532574 @default.
- W2849590047 cites W1994638693 @default.
- W2849590047 cites W1997508706 @default.
- W2849590047 cites W2007706719 @default.
- W2849590047 cites W2013243629 @default.
- W2849590047 cites W2025173623 @default.
- W2849590047 cites W2035649282 @default.
- W2849590047 cites W2045498383 @default.
- W2849590047 cites W2056598826 @default.
- W2849590047 cites W2066322558 @default.
- W2849590047 cites W2079983025 @default.
- W2849590047 cites W2093842837 @default.
- W2849590047 cites W2096921306 @default.
- W2849590047 cites W2102457739 @default.
- W2849590047 cites W2104135721 @default.
- W2849590047 cites W2106448072 @default.
- W2849590047 cites W2107277218 @default.
- W2849590047 cites W2111035891 @default.
- W2849590047 cites W2115654703 @default.
- W2849590047 cites W2123270129 @default.
- W2849590047 cites W2129081579 @default.
- W2849590047 cites W2135647797 @default.
- W2849590047 cites W2140380746 @default.
- W2849590047 cites W2148371571 @default.
- W2849590047 cites W2149743247 @default.
- W2849590047 cites W2155761636 @default.
- W2849590047 cites W2157933861 @default.
- W2849590047 cites W2163975618 @default.
- W2849590047 cites W2165592782 @default.
- W2849590047 cites W2290737450 @default.
- W2849590047 cites W2315219108 @default.
- W2849590047 cites W2344803633 @default.
- W2849590047 cites W2568452295 @default.
- W2849590047 cites W2614673842 @default.
- W2849590047 doi "https://doi.org/10.1172/jci97192" @default.
- W2849590047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6063482" @default.
- W2849590047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29985167" @default.
- W2849590047 hasPublicationYear "2018" @default.
- W2849590047 type Work @default.
- W2849590047 sameAs 2849590047 @default.
- W2849590047 citedByCount "169" @default.
- W2849590047 countsByYear W28495900472018 @default.
- W2849590047 countsByYear W28495900472019 @default.
- W2849590047 countsByYear W28495900472020 @default.
- W2849590047 countsByYear W28495900472021 @default.
- W2849590047 countsByYear W28495900472022 @default.
- W2849590047 countsByYear W28495900472023 @default.
- W2849590047 crossrefType "journal-article" @default.
- W2849590047 hasAuthorship W2849590047A5015038317 @default.
- W2849590047 hasAuthorship W2849590047A5026650904 @default.
- W2849590047 hasAuthorship W2849590047A5026667794 @default.
- W2849590047 hasAuthorship W2849590047A5030823404 @default.
- W2849590047 hasAuthorship W2849590047A5038164428 @default.
- W2849590047 hasAuthorship W2849590047A5050716279 @default.
- W2849590047 hasAuthorship W2849590047A5062882861 @default.
- W2849590047 hasAuthorship W2849590047A5064842155 @default.
- W2849590047 hasAuthorship W2849590047A5071148454 @default.
- W2849590047 hasAuthorship W2849590047A5085888535 @default.
- W2849590047 hasAuthorship W2849590047A5086937841 @default.
- W2849590047 hasBestOaLocation W28495900471 @default.
- W2849590047 hasConcept C121608353 @default.
- W2849590047 hasConcept C126322002 @default.
- W2849590047 hasConcept C142724271 @default.
- W2849590047 hasConcept C164705383 @default.
- W2849590047 hasConcept C181152851 @default.
- W2849590047 hasConcept C203014093 @default.
- W2849590047 hasConcept C2776636583 @default.
- W2849590047 hasConcept C2776914184 @default.
- W2849590047 hasConcept C2776992346 @default.
- W2849590047 hasConcept C2779013556 @default.
- W2849590047 hasConcept C500558357 @default.
- W2849590047 hasConcept C502942594 @default.
- W2849590047 hasConcept C71924100 @default.
- W2849590047 hasConcept C8891405 @default.