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- W28499062 abstract "Cellular functions are outcomes of complex protein assemblies interacting in space and time. Bacterial cell division is an example of this organization. The discovery of MinCDE oscillation in Escherichia coli is a recent demonstration of spatial and temporal patterns arising from seemly simple interacting components. The physics of the MinCDE system has been reviewed elsewhere, but the Min system seems to only exist to regulate another fascinatingly complex process: bacterial cytokinesis. A division organelle – the Z-ring – consisting of 10–20 gene products is responsible for cytokinesis, and every component of the Z-ring is dynamic throughout the cell cycle. While the functions of these components are presently not completely understood, the essential components have been identified, and some of their physical properties have been measured. Moreover, it is becoming clear that the bacterial cells utilize mechanical forces to regulate morphogenesis and division. The Z-ring exerts a contractile force that influences cell wall growth, and thus generating a division septum. This chapter discusses the physics behind bacterial cell wall growth and shape maintenance, the properties of FtsZ and its role in scaffolding and contraction during division. In the process, we hope to reveal the mechanisms that can quantitatively explain bacterial cytokinesis." @default.
- W28499062 created "2016-06-24" @default.
- W28499062 creator A5033299619 @default.
- W28499062 date "2012-01-01" @default.
- W28499062 modified "2023-09-25" @default.
- W28499062 title "7.6 Biophysics of Bacterial Cell Growth and Division" @default.
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- W28499062 doi "https://doi.org/10.1016/b978-0-12-374920-8.00706-2" @default.
- W28499062 hasPublicationYear "2012" @default.
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