Matches in SemOpenAlex for { <https://semopenalex.org/work/W28510545> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W28510545 endingPage "xiv" @default.
- W28510545 startingPage "xiii" @default.
- W28510545 abstract "The last four decades of the 20th century saw the discovery of the heat shock or cell stress response and the identification of the proteins produced by cells in response to adverse environmental conditions. In 1987, the term ‘molecular chaperone’ was coined to describe several unrelated protein families which had the ability to assist the correct folding and assembly/disassembly of other proteins. The past 20 years have seen the elucidation of the structural mechanisms of protein chaperoning by several key molecules including chaperonin (Hsp) 60 and Hsp70 and the realisation that not all molecular chaperones are cell stress proteins and vice versa. The genesis of molecular chaperones was contemporaneous with the identification of these highly conserved proteins as paradoxical immunodominant antigens that appeared to be important in microbial infection and autoimmunity. Indeed, the administration of molecular chaperones such as Hsp60 and Hsp70 was found to inhibit experimental autoimmune disease. By the 1990s, it was realised that correct protein folding was the key to cellular homeostasis and the paradigm that developed was that molecular chaperones were intracellular proteins whose function was to assist in protein folding. The paradoxical immunogenicity and immunomodulatory effects of molecular chaperones remained unexplained." @default.
- W28510545 created "2016-06-24" @default.
- W28510545 creator A5028189994 @default.
- W28510545 creator A5063065323 @default.
- W28510545 date "2005-07-18" @default.
- W28510545 modified "2023-09-27" @default.
- W28510545 title "Preface" @default.
- W28510545 doi "https://doi.org/10.1017/cbo9780511546310.001" @default.
- W28510545 hasPublicationYear "2005" @default.
- W28510545 type Work @default.
- W28510545 sameAs 28510545 @default.
- W28510545 citedByCount "0" @default.
- W28510545 crossrefType "book-chapter" @default.
- W28510545 hasAuthorship W28510545A5028189994 @default.
- W28510545 hasAuthorship W28510545A5063065323 @default.
- W28510545 hasConcept C104317684 @default.
- W28510545 hasConcept C139447449 @default.
- W28510545 hasConcept C141109615 @default.
- W28510545 hasConcept C142724271 @default.
- W28510545 hasConcept C146621620 @default.
- W28510545 hasConcept C147483822 @default.
- W28510545 hasConcept C158617107 @default.
- W28510545 hasConcept C204328495 @default.
- W28510545 hasConcept C205260736 @default.
- W28510545 hasConcept C2775962898 @default.
- W28510545 hasConcept C2780130043 @default.
- W28510545 hasConcept C2780868878 @default.
- W28510545 hasConcept C54355233 @default.
- W28510545 hasConcept C55493867 @default.
- W28510545 hasConcept C61397870 @default.
- W28510545 hasConcept C68991219 @default.
- W28510545 hasConcept C70721500 @default.
- W28510545 hasConcept C71924100 @default.
- W28510545 hasConcept C85755625 @default.
- W28510545 hasConcept C86803240 @default.
- W28510545 hasConcept C8891405 @default.
- W28510545 hasConcept C95444343 @default.
- W28510545 hasConceptScore W28510545C104317684 @default.
- W28510545 hasConceptScore W28510545C139447449 @default.
- W28510545 hasConceptScore W28510545C141109615 @default.
- W28510545 hasConceptScore W28510545C142724271 @default.
- W28510545 hasConceptScore W28510545C146621620 @default.
- W28510545 hasConceptScore W28510545C147483822 @default.
- W28510545 hasConceptScore W28510545C158617107 @default.
- W28510545 hasConceptScore W28510545C204328495 @default.
- W28510545 hasConceptScore W28510545C205260736 @default.
- W28510545 hasConceptScore W28510545C2775962898 @default.
- W28510545 hasConceptScore W28510545C2780130043 @default.
- W28510545 hasConceptScore W28510545C2780868878 @default.
- W28510545 hasConceptScore W28510545C54355233 @default.
- W28510545 hasConceptScore W28510545C55493867 @default.
- W28510545 hasConceptScore W28510545C61397870 @default.
- W28510545 hasConceptScore W28510545C68991219 @default.
- W28510545 hasConceptScore W28510545C70721500 @default.
- W28510545 hasConceptScore W28510545C71924100 @default.
- W28510545 hasConceptScore W28510545C85755625 @default.
- W28510545 hasConceptScore W28510545C86803240 @default.
- W28510545 hasConceptScore W28510545C8891405 @default.
- W28510545 hasConceptScore W28510545C95444343 @default.
- W28510545 hasLocation W285105451 @default.
- W28510545 hasOpenAccess W28510545 @default.
- W28510545 hasPrimaryLocation W285105451 @default.
- W28510545 hasRelatedWork W1603717990 @default.
- W28510545 hasRelatedWork W1952548524 @default.
- W28510545 hasRelatedWork W2018641097 @default.
- W28510545 hasRelatedWork W2050148297 @default.
- W28510545 hasRelatedWork W2056353837 @default.
- W28510545 hasRelatedWork W2167924958 @default.
- W28510545 hasRelatedWork W2407415802 @default.
- W28510545 hasRelatedWork W2945262074 @default.
- W28510545 hasRelatedWork W4313068338 @default.
- W28510545 hasRelatedWork W2186923488 @default.
- W28510545 isParatext "false" @default.
- W28510545 isRetracted "false" @default.
- W28510545 magId "28510545" @default.
- W28510545 workType "book-chapter" @default.