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• W2852753244 abstract "<br><b>OBJECTIVES:</b> Urinary tract infection (UTI) is a frequent disorder and depends on age and gender. Ineffective empiric treatment of UTI is common when associated with extended-spectrum beta-lactamase (ESBL)-producing <i>Escherichia coli</i> and <i>Klebsiella pneumoniae</i>. The aim of the study was to investigate the prevalence of Gram-negative uropathogens of <i>E. coli</i> and <i>K. pneumoniae</i> in different age groups along with the identification of ESBL-producing uropathogens and antimicrobial susceptibility profiles.<br><b>MATERIALS AND METHODS:</b> A total of 247 uropathogens of <i>E. coli</i> and <i>K. pneumoniae</i> were collected over a period of 1 year (January–December 2015) from various diagnostic centers of Karachi city (Pakistan). Antimicrobial susceptibility analysis was performed by disc diffusion method, and identification of ESBL was performed by double disc synergy test. Categorical data of ESBL and non-ESBL uropathogens were analyzed by Pearson's Chi-square test.<br><b>RESULTS:</b> The study of 247 patients with community-acquired UTI comprised 72% females and 28% males, illustrating an increased prevalence of UTIs among females. It was also revealed that 90% belonged to the age group of 16–30 years whereas 78% related to the age group of 46–60 years. ESBL was found positive in 33.5% (63/188) of <i>E. coli</i> and 15.25% (9/59) in <i>K. pneumonia</i>, with a significant association i.e., (p=0.007). Amikacin, fosfomycin, imipenem, and tazobactam/piperacillin were found to be the effective treatment options. A significant association was found between ESBL-producing uropathogens against ciprofloxacin, enoxacin, and amoxicillin/clavulanic acid resistance (<i>P</i> < 0.05).<br><b>CONCLUSIONS:</b> It was concluded that for effective treatment of UTIs, appropriate screening of ESBL and culture sensitivity must be employed instead of empiric treatment.<br>" @default.
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• W2852753244 date "2018-01-01" @default.
• W2852753244 modified "2023-09-27" @default.
• W2852753244 title "Incidence of multidrug resistance and extended-spectrum beta-lactamase expression in community-acquired urinary tract infection among different age groups of patients" @default.
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• W2852753244 doi "https://doi.org/10.4103/ijp.ijp_200_17" @default.
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