FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W28543623> ?p ?o ?g. }

• W28543623 abstract "Psychomotor stimulant abuse is a significant public health problem. While many individuals experiment with stimulants, there is marked variability in individuals’ behavioral and subjective response to these drugs and these differences may be associated with their risk for abuse. One characteristic shown to be associated with drug abuse is sensation seeking, defined as the seeking of novel sensations and experiences and the willingness to take risks for the sake of such experiences. While observational studies have shown that individuals with elevated sensation seeking are more likely to report stimulant use and abuse, less clear is whether subjective and behavioral response to acute stimulant administration may vary as a function of sensation seeking status. We recently completed an outpatient laboratory study in which 37 healthy adults received repeated opportunities to sample and choose between d-amphetamine (d-AMPH; 5, 10, 20 mg/70kg) or placebo. That study provided an opportunity to examine associations between sensation seeking and d-AMPH choice and subjective response under rigorous double-blind experimental conditions. The Zuckerman Sensation Seeking Scale V was administered at intake, providing a Total sensation seeking score as well as four subscales (i.e., Experience Seeking, Disinhibition, Thrill and Adventure Seeking, Boredom Susceptibility). We hypothesized that elevated sensation seeking at intake would be associated with increased preference for d-AMPH over placebo in subsequent choice sessions, as well as greater positive d-AMPH subjective effects. Among males, increased baseline sensation seeking was associated with increased d-AMPH choice and positive subjective effects at the 5 and 10 mg/70 kg doses. Among females we found no significant associations between sensation seeking and d-AMPH choice or subjective effects. Finally, when the association between sensation seeking and other baseline characteristics was examined, there was a significant positive association with lifetime drug use as well as impulsivity. Taken together, our data suggest that elevated sensation seeking in males may be associated with increased sensitivity to d-AMPH reinforcement and positive subjective effects, suggesting increased vulnerability for stimulant use and abuse." @default.
• W28543623 created "2016-06-24" @default.
• W28543623 creator A5020655830 @default.
• W28543623 date "2014-01-01" @default.
• W28543623 modified "2023-09-27" @default.
• W28543623 title "Role of sensation seeking in sensitivity to d-amphetamine reinforcement" @default.
• W28543623 cites W1499078296 @default.
• W28543623 cites W1563873975 @default.
• W28543623 cites W1607171655 @default.
• W28543623 cites W1760119900 @default.
• W28543623 cites W1964006502 @default.
• W28543623 cites W1967332436 @default.
• W28543623 cites W1981764450 @default.
• W28543623 cites W1982340927 @default.
• W28543623 cites W1984750558 @default.
• W28543623 cites W1987329516 @default.
• W28543623 cites W1987838173 @default.
• W28543623 cites W1990527783 @default.
• W28543623 cites W1992455356 @default.
• W28543623 cites W1992920805 @default.
• W28543623 cites W1995328751 @default.
• W28543623 cites W1998386693 @default.
• W28543623 cites W2012961182 @default.
• W28543623 cites W2014083132 @default.
• W28543623 cites W2016223784 @default.
• W28543623 cites W2017348786 @default.
• W28543623 cites W2017726044 @default.
• W28543623 cites W2025897227 @default.
• W28543623 cites W2032714267 @default.
• W28543623 cites W2032765597 @default.
• W28543623 cites W2033200028 @default.
• W28543623 cites W2037704381 @default.
• W28543623 cites W2040278614 @default.
• W28543623 cites W2042017134 @default.
• W28543623 cites W2047008175 @default.
• W28543623 cites W2047386861 @default.
• W28543623 cites W2048263031 @default.
• W28543623 cites W2049787786 @default.
• W28543623 cites W2052858063 @default.
• W28543623 cites W2053978131 @default.
• W28543623 cites W2054018702 @default.
• W28543623 cites W2054515032 @default.
• W28543623 cites W2057464476 @default.
• W28543623 cites W2060097054 @default.
• W28543623 cites W2061394054 @default.
• W28543623 cites W2061587195 @default.
• W28543623 cites W2061795745 @default.
• W28543623 cites W2062351163 @default.
• W28543623 cites W2062877668 @default.
• W28543623 cites W2063344279 @default.
• W28543623 cites W2068986513 @default.
• W28543623 cites W2072833030 @default.
• W28543623 cites W2073965343 @default.
• W28543623 cites W2075227200 @default.
• W28543623 cites W2077451967 @default.
• W28543623 cites W2077620252 @default.
• W28543623 cites W2080044632 @default.
• W28543623 cites W2080215367 @default.
• W28543623 cites W2082927185 @default.
• W28543623 cites W2084511194 @default.
• W28543623 cites W2086577965 @default.
• W28543623 cites W2089057386 @default.
• W28543623 cites W2092558173 @default.
• W28543623 cites W2093372795 @default.
• W28543623 cites W2094919419 @default.
• W28543623 cites W2103190374 @default.
• W28543623 cites W2107554252 @default.
• W28543623 cites W2111376301 @default.
• W28543623 cites W2112104149 @default.
• W28543623 cites W2113324723 @default.
• W28543623 cites W2115610172 @default.
• W28543623 cites W2118865547 @default.
• W28543623 cites W2119314959 @default.
• W28543623 cites W2127854642 @default.
• W28543623 cites W2128657693 @default.
• W28543623 cites W2130237886 @default.
• W28543623 cites W2132471356 @default.
• W28543623 cites W2139598792 @default.
• W28543623 cites W2146360850 @default.
• W28543623 cites W2146835230 @default.
• W28543623 cites W2148780165 @default.
• W28543623 cites W2161028166 @default.
• W28543623 cites W2323042322 @default.
• W28543623 cites W2326429274 @default.
• W28543623 cites W2347176569 @default.
• W28543623 cites W2399045151 @default.
• W28543623 cites W2400242479 @default.
• W28543623 cites W2413100764 @default.
• W28543623 cites W2414270147 @default.
• W28543623 cites W2489691480 @default.
• W28543623 cites W2798204804 @default.
• W28543623 cites W3217134939 @default.
• W28543623 cites W93546378 @default.
• W28543623 hasPublicationYear "2014" @default.
• W28543623 type Work @default.
• W28543623 sameAs 28543623 @default.
• W28543623 citedByCount "0" @default.
• W28543623 crossrefType "journal-article" @default.
• W28543623 hasAuthorship W28543623A5020655830 @default.
• W28543623 hasConcept C115816405 @default.

• next