FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2854608545> ?p ?o ?g. }

• W2854608545 endingPage "66" @default.
• W2854608545 startingPage "59" @default.
• W2854608545 abstract "Much evidence indicates that the soluble antigens secreted by hepatitis B virus (HBV) inhibit the function of the immune system. The aim of this study is to investigate, after treatment with nucleoside (acid) analogs (NAs) and the inhibition of viral replication, whether the immune systems of patients with a peripheral blood HBV-DNA level <1000 IU/mL, hepatitis B e antigen (HBeAg) disappearance, and a decrease in hepatitis B surface antigen (HBsAg) levels could be reconstructed. The frequency and phenotype of circulating natural killer (NK) cells, dendritic cells (DCs), T-helper (Th) cells, regulatory T (Treg) cells, CD4+, CD8+ T cells, T follicular helper (Tfh) cells and B cells subtypes were tested by flow cytometry in chronic hepatitis B (CHB) patients and healthy controls (HCs). The levels of HBV-related serum HBsAg, HBeAg, HBV-DNA load, alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were determined. Regarding the innate immune system, an increased frequency of CD56dim NK cells was found in the therapeutic response (TR) group compared with that in the immune-active phase (IA) group. Additionally, regarding the adaptive immune system, the Th17/CD4+CD25+CD127dimTreg ratio was reduced in the TR group. Additionally, the frequency of CD40L+CXCR5+CD4+T cells and CD40+CD19+CD27+CD38+B cells was significantly higher than that of HCs, while that of PDL1+CD19+ B cells was lower. Furthermore, the frequencies of CTLA4+CD4+T cells and CTLA4+CD8+T cells in patients with CHB were significantly higher than those in HCs. After NA treatment and the inhibition of viral replication, circulating CD56dim NK cells and the balance of Th17/Treg can be recovered. Restoring circulating CD56dim NK cells and the Th17/Treg balance may help reduce HBsAg levels in patients." @default.
• W2854608545 created "2018-07-19" @default.
• W2854608545 creator A5006570272 @default.
• W2854608545 creator A5012718640 @default.
• W2854608545 creator A5013349525 @default.
• W2854608545 creator A5016396916 @default.
• W2854608545 creator A5020799863 @default.
• W2854608545 creator A5024010575 @default.
• W2854608545 creator A5045791329 @default.
• W2854608545 creator A5047688028 @default.
• W2854608545 creator A5048826252 @default.
• W2854608545 creator A5066716873 @default.
• W2854608545 creator A5077357809 @default.
• W2854608545 date "2018-09-01" @default.
• W2854608545 modified "2023-10-15" @default.
• W2854608545 title "Recovery of circulating CD56dim NK cells and the balance of Th17/Treg after nucleoside analog therapy in patients with chronic hepatitis B and low levels of HBsAg" @default.
• W2854608545 cites W1920636557 @default.
• W2854608545 cites W1965827638 @default.
• W2854608545 cites W1972264612 @default.
• W2854608545 cites W1973681037 @default.
• W2854608545 cites W1979809055 @default.
• W2854608545 cites W1989095325 @default.
• W2854608545 cites W2006774237 @default.
• W2854608545 cites W2007585461 @default.
• W2854608545 cites W2010845447 @default.
• W2854608545 cites W2031586632 @default.
• W2854608545 cites W2047206208 @default.
• W2854608545 cites W2073300038 @default.
• W2854608545 cites W2096094255 @default.
• W2854608545 cites W2098187829 @default.
• W2854608545 cites W2098891215 @default.
• W2854608545 cites W2105289311 @default.
• W2854608545 cites W2166877704 @default.
• W2854608545 cites W2174723704 @default.
• W2854608545 cites W2248623199 @default.
• W2854608545 cites W2299872562 @default.
• W2854608545 cites W2337204897 @default.
• W2854608545 cites W2403400382 @default.
• W2854608545 cites W2429956850 @default.
• W2854608545 cites W2542869238 @default.
• W2854608545 cites W2561926137 @default.
• W2854608545 cites W2578448892 @default.
• W2854608545 cites W2074367442 @default.
• W2854608545 doi "https://doi.org/10.1016/j.intimp.2018.06.043" @default.
• W2854608545 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29990695" @default.
• W2854608545 hasPublicationYear "2018" @default.
• W2854608545 type Work @default.
• W2854608545 sameAs 2854608545 @default.
• W2854608545 citedByCount "21" @default.
• W2854608545 countsByYear W28546085452018 @default.
• W2854608545 countsByYear W28546085452020 @default.
• W2854608545 countsByYear W28546085452021 @default.
• W2854608545 countsByYear W28546085452022 @default.
• W2854608545 countsByYear W28546085452023 @default.
• W2854608545 crossrefType "journal-article" @default.
• W2854608545 hasAuthorship W2854608545A5006570272 @default.
• W2854608545 hasAuthorship W2854608545A5012718640 @default.
• W2854608545 hasAuthorship W2854608545A5013349525 @default.
• W2854608545 hasAuthorship W2854608545A5016396916 @default.
• W2854608545 hasAuthorship W2854608545A5020799863 @default.
• W2854608545 hasAuthorship W2854608545A5024010575 @default.
• W2854608545 hasAuthorship W2854608545A5045791329 @default.
• W2854608545 hasAuthorship W2854608545A5047688028 @default.
• W2854608545 hasAuthorship W2854608545A5048826252 @default.
• W2854608545 hasAuthorship W2854608545A5066716873 @default.
• W2854608545 hasAuthorship W2854608545A5077357809 @default.
• W2854608545 hasConcept C10205521 @default.
• W2854608545 hasConcept C129374314 @default.
• W2854608545 hasConcept C147483822 @default.
• W2854608545 hasConcept C149532602 @default.
• W2854608545 hasConcept C154317977 @default.
• W2854608545 hasConcept C159912055 @default.
• W2854608545 hasConcept C167672396 @default.
• W2854608545 hasConcept C193419808 @default.
• W2854608545 hasConcept C202751555 @default.
• W2854608545 hasConcept C203014093 @default.
• W2854608545 hasConcept C2522874641 @default.
• W2854608545 hasConcept C2775940106 @default.
• W2854608545 hasConcept C2776090121 @default.
• W2854608545 hasConcept C2777382497 @default.
• W2854608545 hasConcept C2777410769 @default.
• W2854608545 hasConcept C2778957590 @default.
• W2854608545 hasConcept C2780127873 @default.
• W2854608545 hasConcept C2780593183 @default.
• W2854608545 hasConcept C28328180 @default.
• W2854608545 hasConcept C39347974 @default.
• W2854608545 hasConcept C54355233 @default.
• W2854608545 hasConcept C55493867 @default.
• W2854608545 hasConcept C71924100 @default.
• W2854608545 hasConcept C79484868 @default.
• W2854608545 hasConcept C86803240 @default.
• W2854608545 hasConcept C8891405 @default.
• W2854608545 hasConceptScore W2854608545C10205521 @default.
• W2854608545 hasConceptScore W2854608545C129374314 @default.
• W2854608545 hasConceptScore W2854608545C147483822 @default.
• W2854608545 hasConceptScore W2854608545C149532602 @default.
• W2854608545 hasConceptScore W2854608545C154317977 @default.
• W2854608545 hasConceptScore W2854608545C159912055 @default.

• next