FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2854828504> ?p ?o ?g. }

• W2854828504 abstract "The effects of the selective AT 2 R (angiotensin AT2 receptor) agonist, Compound 21 (C21), on abdominal aortic aneurysm formation were investigated in normotensive Wistar rats. Abdominal aortic aneurysm was induced by perfusion of isolated aortic segments with elastase. Treatment with C21 (0.03 mg/kg daily) was started after operation and continued for 14 days. Sham-operated animals and vehicle-treated animals after aneurysm induction served as controls. Aortic diameter, aortic wall distensibility, and pulse propagation velocity were measured via ultrasound. Hemodynamic parameters, aortic tissue protein expression, and serum cytokines were analyzed. On day 14 post aneurysm induction, aortic diameter of vehicle-treated animals was increased 1.6-fold compared with sham-operated rats (2.65±0.05 versus 1.70±0.06 mm; P <0.0001). C21 decreased aortic diameter in comparison to vehicle (1.9±0.06 versus 2.65±0.05; P <0.0001). Infrarenal blood velocity and aortic distensibility were reduced, whereas aortic wall stiffness was increased post aneurysm induction. These alterations were significantly ameliorated by treatment with C21 while blood pressure and cardiac contractility remained unchanged. Protein expression of IL-1β (interleukin-1β), NFκB (nuclear factor κB), MMP9 (matrix metalloproteinase 9), TGF-β1 (transforming growth factor-β1), and MLKL (mixed lineage kinase domain-like) in the aorta was significantly ( P <0.05) down-regulated in the C21 group compared with vehicle. Serum concentration of TGF-β1 was decreased by C21 in comparison to vehicle ( P <0.01). AT 2 R stimulation with C21 prevented extracellular matrix degradation, maintained vascular integrity of the aorta and prevented abdominal aortic aneurysm progression." @default.
• W2854828504 created "2018-07-19" @default.
• W2854828504 creator A5005031786 @default.
• W2854828504 creator A5027579803 @default.
• W2854828504 creator A5044779445 @default.
• W2854828504 creator A5052836637 @default.
• W2854828504 creator A5086854477 @default.
• W2854828504 creator A5090640197 @default.
• W2854828504 date "2018-09-01" @default.
• W2854828504 modified "2023-10-01" @default.
• W2854828504 title "AT ₂ R (Angiotensin AT2 Receptor) Agonist, Compound 21, Prevents Abdominal Aortic Aneurysm Progression in the Rat" @default.
• W2854828504 cites W1874170221 @default.
• W2854828504 cites W1976834631 @default.
• W2854828504 cites W1988167553 @default.
• W2854828504 cites W1991684208 @default.
• W2854828504 cites W2012481791 @default.
• W2854828504 cites W2023122823 @default.
• W2854828504 cites W2025573820 @default.
• W2854828504 cites W2033325833 @default.
• W2854828504 cites W2036015557 @default.
• W2854828504 cites W2041237859 @default.
• W2854828504 cites W2047110284 @default.
• W2854828504 cites W2056364373 @default.
• W2854828504 cites W2057021221 @default.
• W2854828504 cites W2057185378 @default.
• W2854828504 cites W2065556887 @default.
• W2854828504 cites W2066270582 @default.
• W2854828504 cites W2066720058 @default.
• W2854828504 cites W2067142583 @default.
• W2854828504 cites W2080071215 @default.
• W2854828504 cites W2083363729 @default.
• W2854828504 cites W2083601199 @default.
• W2854828504 cites W2083672320 @default.
• W2854828504 cites W2087171325 @default.
• W2854828504 cites W2091614247 @default.
• W2854828504 cites W2099769124 @default.
• W2854828504 cites W2099825476 @default.
• W2854828504 cites W2109329928 @default.
• W2854828504 cites W2112903359 @default.
• W2854828504 cites W2113301098 @default.
• W2854828504 cites W2113762991 @default.
• W2854828504 cites W2114317863 @default.
• W2854828504 cites W2131098432 @default.
• W2854828504 cites W2134723973 @default.
• W2854828504 cites W2140474152 @default.
• W2854828504 cites W2162701611 @default.
• W2854828504 cites W2163041161 @default.
• W2854828504 cites W2169617706 @default.
• W2854828504 cites W2176032091 @default.
• W2854828504 cites W2194598765 @default.
• W2854828504 cites W2566459473 @default.
• W2854828504 cites W2610430195 @default.
• W2854828504 cites W2660612301 @default.
• W2854828504 cites W2726705340 @default.
• W2854828504 cites W2770613425 @default.
• W2854828504 doi "https://doi.org/10.1161/hypertensionaha.118.11168" @default.
• W2854828504 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29987108" @default.
• W2854828504 hasPublicationYear "2018" @default.
• W2854828504 type Work @default.
• W2854828504 sameAs 2854828504 @default.
• W2854828504 citedByCount "25" @default.
• W2854828504 countsByYear W28548285042018 @default.
• W2854828504 countsByYear W28548285042019 @default.
• W2854828504 countsByYear W28548285042020 @default.
• W2854828504 countsByYear W28548285042021 @default.
• W2854828504 countsByYear W28548285042022 @default.
• W2854828504 countsByYear W28548285042023 @default.
• W2854828504 crossrefType "journal-article" @default.
• W2854828504 hasAuthorship W2854828504A5005031786 @default.
• W2854828504 hasAuthorship W2854828504A5027579803 @default.
• W2854828504 hasAuthorship W2854828504A5044779445 @default.
• W2854828504 hasAuthorship W2854828504A5052836637 @default.
• W2854828504 hasAuthorship W2854828504A5086854477 @default.
• W2854828504 hasAuthorship W2854828504A5090640197 @default.
• W2854828504 hasBestOaLocation W28548285041 @default.
• W2854828504 hasConcept C126322002 @default.
• W2854828504 hasConcept C134018914 @default.
• W2854828504 hasConcept C141071460 @default.
• W2854828504 hasConcept C164705383 @default.
• W2854828504 hasConcept C170493617 @default.
• W2854828504 hasConcept C178853913 @default.
• W2854828504 hasConcept C2776098176 @default.
• W2854828504 hasConcept C2776885963 @default.
• W2854828504 hasConcept C2777323849 @default.
• W2854828504 hasConcept C2778122271 @default.
• W2854828504 hasConcept C2778938600 @default.
• W2854828504 hasConcept C2779980429 @default.
• W2854828504 hasConcept C2779993416 @default.
• W2854828504 hasConcept C2780520971 @default.
• W2854828504 hasConcept C2908929049 @default.
• W2854828504 hasConcept C71924100 @default.
• W2854828504 hasConceptScore W2854828504C126322002 @default.
• W2854828504 hasConceptScore W2854828504C134018914 @default.
• W2854828504 hasConceptScore W2854828504C141071460 @default.
• W2854828504 hasConceptScore W2854828504C164705383 @default.
• W2854828504 hasConceptScore W2854828504C170493617 @default.
• W2854828504 hasConceptScore W2854828504C178853913 @default.
• W2854828504 hasConceptScore W2854828504C2776098176 @default.
• W2854828504 hasConceptScore W2854828504C2776885963 @default.
• W2854828504 hasConceptScore W2854828504C2777323849 @default.

• next