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- W285489405 abstract "At present,the occurrence of first modulation of pain transmission in the superficial dorsal horn, especially in the substantia gelatinosa (SG: lamina II),is firmly established. Nociceptive primary,afferent central terminals (C-terminal) arising from nonmyelinated C-fibers and myelinated Aδ- fibers terminate in the SG and make synaptic glomeruli,in which they are centrally situated and surrounded by a number of dendrites and a few axonal terminals. One of the structural characteristics of C-terminals is indented,sinuous,or scalloped electron-dense axoplasm full of round synaptic vesicles (CI-terminal), while an other is larger roundish, electron-lucent axoplasm with many large dense core vesicles and mitochondria (CII-terminal). They are FRAP-and SP-or CGRP-positive and show intense capsaicinsensitivity. lnhibitory interneurons containing GABA,glycine or opioids are exclusively present in the SG. They contact with C-terminals,forming synaptic glomeruli. However,the synaptic relationship between C-terminals and inhibitory interneurons is controversial,i.e.,the postsynaptic contacts of inhibitory interneurons to C-terminals is not accepted. However,from previous reports concerning these synaptic structures,the presynaptic relationship of C-fibers to the inhibitory interneurons seem to be more enhanced,although species differences might be present." @default.
- W285489405 created "2016-06-24" @default.
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- W285489405 date "2007-01-01" @default.
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- W285489405 title "The controversial issue of the synaptic structure underlying pain modulation in the superficial dorsal horn of the spinal cord" @default.
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