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- W2855676216 abstract "The aim was to investigate the levels of cytokines and soluble IL-6R in the tears of patients with thyroid-associated orbitopathy (TAO) disease. Schirmer's test was adopted to collect tears from TAO patients (N = 20, 17 women, mean age (±SD): 46.0 years (±13.4)) and healthy subjects (N = 18, 10 women, 45.4 years (±18.7)). Lacrimal cytokines and soluble IL-6R (sIL-6R) were measured using a 10-plex panel (Meso Scale Discovery Company) and Invitrogen Human sIL-6R Elisa kit, respectively. Tear levels of IL-10, IL-12p70, IL-13, IL-6 and TNF-α appeared significantly higher in TAO patients than in healthy subjects. Interestingly, IL-10, IL-12p70 and IL-8 levels increased in tears whatever the form of TAO whereas IL-13, IL-6 and TNF-α levels were significantly elevated in inflammatory TAO patients, meaning with a clinical score activity (CAS) ≥ 3, compared to controls. Furthermore, only 3 cytokines were strongly positively correlated with CAS (IL-13 Spearman coeff. r: 0.703, p = 0.0005; IL-6 r: 0.553, p = 0.011; IL-8 r: 0.618, p = 0.004, respectively). Finally, tobacco use disturbed the levels of several cytokines, especially in patient suffering of TAO. The differential profile of lacrimal cytokines could be useful for the diagnosis of TAO patients. Nevertheless, the tobacco use of these patients should be taken into account in the interpretation of the cytokine levels." @default.
- W2855676216 created "2018-07-19" @default.
- W2855676216 creator A5012479222 @default.
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- W2855676216 date "2018-07-17" @default.
- W2855676216 modified "2023-09-26" @default.
- W2855676216 title "Differential profiling of lacrimal cytokines in patients suffering from thyroid-associated orbitopathy" @default.
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- W2855676216 doi "https://doi.org/10.1038/s41598-018-29113-2" @default.
- W2855676216 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6050228" @default.
- W2855676216 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30018377" @default.
- W2855676216 hasPublicationYear "2018" @default.
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