Matches in SemOpenAlex for { <https://semopenalex.org/work/W2855761366> ?p ?o ?g. }
- W2855761366 endingPage "1907" @default.
- W2855761366 startingPage "1897" @default.
- W2855761366 abstract "Experimental and clinical findings suggest a crucial role for inflammation in the onset of pediatric seizures; this mechanism is not targeted by conventional antiepileptic drugs and may contribute to refractory epilepsy. Several triggers, including infection with neurotropic viruses such as human herpesvirus 6 (HHV-6), other herpesviruses, and picornaviruses, appear to induce activation of the innate and adaptive immune systems, which results in several neuroinflammatory responses, leading to enhanced neuronal excitability, and ultimately contributing to epileptogenesis. This review discusses the proposed mechanisms by which infection with herpesviruses, and particularly with HHV-6, and ensuing inflammation may lead to seizure generation, and later development of epilepsy. We also examine the evidence that links herpesvirus and picornavirus infections with acute seizures and chronic forms of epilepsy. Understanding the mechanisms by which specific viruses may trigger a cascade of alterations in the CNS ultimately leading to epilepsy appears critical for the development of therapeutic agents that may target the virus or inflammatory mechanisms early and prevent progression of epileptogenesis." @default.
- W2855761366 created "2018-07-19" @default.
- W2855761366 creator A5040671001 @default.
- W2855761366 creator A5051578610 @default.
- W2855761366 creator A5051928962 @default.
- W2855761366 creator A5052902667 @default.
- W2855761366 creator A5063219454 @default.
- W2855761366 creator A5030902548 @default.
- W2855761366 date "2018-07-05" @default.
- W2855761366 modified "2023-10-17" @default.
- W2855761366 title "Viral Triggers and Inflammatory Mechanisms in Pediatric Epilepsy" @default.
- W2855761366 cites W1482709215 @default.
- W2855761366 cites W1540425213 @default.
- W2855761366 cites W154244393 @default.
- W2855761366 cites W1546055799 @default.
- W2855761366 cites W1548862642 @default.
- W2855761366 cites W1675705467 @default.
- W2855761366 cites W1746603715 @default.
- W2855761366 cites W1767716230 @default.
- W2855761366 cites W1831137467 @default.
- W2855761366 cites W1832832250 @default.
- W2855761366 cites W1847797033 @default.
- W2855761366 cites W1964524014 @default.
- W2855761366 cites W1966994492 @default.
- W2855761366 cites W1971971292 @default.
- W2855761366 cites W1972163933 @default.
- W2855761366 cites W1978525572 @default.
- W2855761366 cites W1978851277 @default.
- W2855761366 cites W1980574125 @default.
- W2855761366 cites W1981539484 @default.
- W2855761366 cites W1981770023 @default.
- W2855761366 cites W1983100194 @default.
- W2855761366 cites W1983659919 @default.
- W2855761366 cites W1984050978 @default.
- W2855761366 cites W1990732344 @default.
- W2855761366 cites W1991399173 @default.
- W2855761366 cites W1996240810 @default.
- W2855761366 cites W1998229400 @default.
- W2855761366 cites W2003877200 @default.
- W2855761366 cites W2004806661 @default.
- W2855761366 cites W2017605505 @default.
- W2855761366 cites W2021163482 @default.
- W2855761366 cites W2022671065 @default.
- W2855761366 cites W2023868271 @default.
- W2855761366 cites W2030263312 @default.
- W2855761366 cites W2034300348 @default.
- W2855761366 cites W2034879833 @default.
- W2855761366 cites W2037419754 @default.
- W2855761366 cites W2038052320 @default.
- W2855761366 cites W2040243107 @default.
- W2855761366 cites W2040958998 @default.
- W2855761366 cites W2042152368 @default.
- W2855761366 cites W2042393720 @default.
- W2855761366 cites W2044236275 @default.
- W2855761366 cites W2044840964 @default.
- W2855761366 cites W2045213112 @default.
- W2855761366 cites W2046904267 @default.
- W2855761366 cites W2047816313 @default.
- W2855761366 cites W2048766596 @default.
- W2855761366 cites W2050295653 @default.
- W2855761366 cites W2050744136 @default.
- W2855761366 cites W2051186074 @default.
- W2855761366 cites W2051764922 @default.
- W2855761366 cites W2052285428 @default.
- W2855761366 cites W2063997699 @default.
- W2855761366 cites W2067283276 @default.
- W2855761366 cites W2068388533 @default.
- W2855761366 cites W2074092900 @default.
- W2855761366 cites W2082696829 @default.
- W2855761366 cites W2083811331 @default.
- W2855761366 cites W2083984052 @default.
- W2855761366 cites W2086587308 @default.
- W2855761366 cites W2088563405 @default.
- W2855761366 cites W2090923633 @default.
- W2855761366 cites W2091405647 @default.
- W2855761366 cites W2092406095 @default.
- W2855761366 cites W2096518479 @default.
- W2855761366 cites W2100510380 @default.
- W2855761366 cites W2104387508 @default.
- W2855761366 cites W2109496063 @default.
- W2855761366 cites W2111044841 @default.
- W2855761366 cites W2112754745 @default.
- W2855761366 cites W2115396398 @default.
- W2855761366 cites W2115669202 @default.
- W2855761366 cites W2115882630 @default.
- W2855761366 cites W2119014382 @default.
- W2855761366 cites W2126274301 @default.
- W2855761366 cites W2128324826 @default.
- W2855761366 cites W2128693261 @default.
- W2855761366 cites W2130089704 @default.
- W2855761366 cites W2131480973 @default.
- W2855761366 cites W2133245384 @default.
- W2855761366 cites W2134209166 @default.
- W2855761366 cites W2135298792 @default.
- W2855761366 cites W2136042143 @default.
- W2855761366 cites W2145799379 @default.
- W2855761366 cites W2146299031 @default.
- W2855761366 cites W2156040144 @default.