Matches in SemOpenAlex for { <https://semopenalex.org/work/W2856333867> ?p ?o ?g. }
- W2856333867 endingPage "177.e6" @default.
- W2856333867 startingPage "169" @default.
- W2856333867 abstract "Activity-dependent changes in neuronal function require coordinated regulation of the protein synthesis and protein degradation machinery to maintain protein homeostasis, critical for proper neuronal function. However, the biochemical evidence for this balance and coordination is largely lacking. Leveraging our recent discovery of a neuronal-specific 20S membrane proteasome complex (NMP), we began exploring how neuronal activity regulates its function. Here, we found that the NMP degrades exclusively a large fraction of ribosome-associated nascent polypeptides that are being newly synthesized during neuronal stimulation. Using deep-coverage and global mass spectrometry, we identified the nascent protein substrates of the NMP, which included products encoding immediate-early genes, such as c-Fos and Npas4. Intriguingly, we found that turnover of nascent polypeptides and not full-length proteins through the NMP occurred independent of canonical ubiquitylation pathways. We propose that these findings generally define a neuronal activity-induced protein homeostasis program of coordinated protein synthesis and degradation through the NMP." @default.
- W2856333867 created "2018-07-19" @default.
- W2856333867 creator A5003988765 @default.
- W2856333867 creator A5018364849 @default.
- W2856333867 creator A5037759360 @default.
- W2856333867 creator A5064985797 @default.
- W2856333867 creator A5078928975 @default.
- W2856333867 creator A5088227240 @default.
- W2856333867 date "2018-07-01" @default.
- W2856333867 modified "2023-10-15" @default.
- W2856333867 title "Activity-Dependent Degradation of the Nascentome by the Neuronal Membrane Proteasome" @default.
- W2856333867 cites W1482915690 @default.
- W2856333867 cites W1540059158 @default.
- W2856333867 cites W1577674984 @default.
- W2856333867 cites W1782287000 @default.
- W2856333867 cites W1958069064 @default.
- W2856333867 cites W1969487900 @default.
- W2856333867 cites W1983404135 @default.
- W2856333867 cites W1986069023 @default.
- W2856333867 cites W1996396557 @default.
- W2856333867 cites W1998708875 @default.
- W2856333867 cites W1999512724 @default.
- W2856333867 cites W2000789682 @default.
- W2856333867 cites W2000874341 @default.
- W2856333867 cites W2006255460 @default.
- W2856333867 cites W2006641649 @default.
- W2856333867 cites W2006900120 @default.
- W2856333867 cites W2013092025 @default.
- W2856333867 cites W2020469828 @default.
- W2856333867 cites W2022783417 @default.
- W2856333867 cites W2025356047 @default.
- W2856333867 cites W2026465178 @default.
- W2856333867 cites W2026663553 @default.
- W2856333867 cites W2026832087 @default.
- W2856333867 cites W2029220273 @default.
- W2856333867 cites W2032057219 @default.
- W2856333867 cites W2038719756 @default.
- W2856333867 cites W2042834556 @default.
- W2856333867 cites W2044307053 @default.
- W2856333867 cites W2047537735 @default.
- W2856333867 cites W2058238065 @default.
- W2856333867 cites W2058861807 @default.
- W2856333867 cites W2059175716 @default.
- W2856333867 cites W2071847586 @default.
- W2856333867 cites W2072977612 @default.
- W2856333867 cites W2079052947 @default.
- W2856333867 cites W2085717111 @default.
- W2856333867 cites W2089865526 @default.
- W2856333867 cites W2096123613 @default.
- W2856333867 cites W2103588346 @default.
- W2856333867 cites W2109851824 @default.
- W2856333867 cites W2118639179 @default.
- W2856333867 cites W2126843591 @default.
- W2856333867 cites W2133593340 @default.
- W2856333867 cites W2135581618 @default.
- W2856333867 cites W2139087276 @default.
- W2856333867 cites W2141927426 @default.
- W2856333867 cites W2151538478 @default.
- W2856333867 cites W2165643659 @default.
- W2856333867 cites W2178503716 @default.
- W2856333867 cites W2180080905 @default.
- W2856333867 cites W2399694841 @default.
- W2856333867 cites W2405939328 @default.
- W2856333867 cites W2473711714 @default.
- W2856333867 cites W2529263647 @default.
- W2856333867 cites W2565793933 @default.
- W2856333867 cites W2578118420 @default.
- W2856333867 cites W2597217272 @default.
- W2856333867 cites W2761249894 @default.
- W2856333867 cites W2774010248 @default.
- W2856333867 cites W2783151804 @default.
- W2856333867 cites W4234586755 @default.
- W2856333867 cites W4300580226 @default.
- W2856333867 doi "https://doi.org/10.1016/j.molcel.2018.06.013" @default.
- W2856333867 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6070390" @default.
- W2856333867 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29979964" @default.
- W2856333867 hasPublicationYear "2018" @default.
- W2856333867 type Work @default.
- W2856333867 sameAs 2856333867 @default.
- W2856333867 citedByCount "57" @default.
- W2856333867 countsByYear W28563338672018 @default.
- W2856333867 countsByYear W28563338672019 @default.
- W2856333867 countsByYear W28563338672020 @default.
- W2856333867 countsByYear W28563338672021 @default.
- W2856333867 countsByYear W28563338672022 @default.
- W2856333867 countsByYear W28563338672023 @default.
- W2856333867 crossrefType "journal-article" @default.
- W2856333867 hasAuthorship W2856333867A5003988765 @default.
- W2856333867 hasAuthorship W2856333867A5018364849 @default.
- W2856333867 hasAuthorship W2856333867A5037759360 @default.
- W2856333867 hasAuthorship W2856333867A5064985797 @default.
- W2856333867 hasAuthorship W2856333867A5078928975 @default.
- W2856333867 hasAuthorship W2856333867A5088227240 @default.
- W2856333867 hasBestOaLocation W28563338671 @default.
- W2856333867 hasConcept C104317684 @default.
- W2856333867 hasConcept C14036430 @default.
- W2856333867 hasConcept C169760540 @default.
- W2856333867 hasConcept C195580219 @default.