FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2857071096> ?p ?o ?g. }

• W2857071096 abstract "The effects of berberine on cardiac function of heart failure after myocardial infarction and its possible mechanism were investigated. The anterior descending branches of 50 female Wistar rats were ligatured to establish the model of heart failure after myocardial infarction. At 4 weeks after successful modeling, the rats were randomly divided into two groups receiving 4-week gavage with saline (Sal group) and berberine (Ber group), while the sham-operation group (Sham group) was set up. After 4 weeks, the hemodynamics and serum BNP in rats were measured. The hearts of rats were taken to detect the degree of myocardial fibrosis. The myocardial cell apoptosis was detected. The expressions and changes in myocardial apoptosis-related proteins, including Bcl-2, Bax and caspase-3, were detected. The expression and changes in GRP78, CHOP and caspase-12 in myocardial tissue were detected. The results showed that Berberine improved the cardiac function of rats after myocardial infarction. After myocardial infarction, myocardial fibrosis and apoptosis were observed around the infarction area, berberine improved the myocardial fibrosis and reduced cell apoptosis. Furthermore, berberine alleviated endoplasmic reticulum stress (ERS) after myocardial infarction. In conclusion, Berberine can inhibit the myocardium cell apoptosis of heart failure after myocardial infarction, and its mechanism may be realized by affecting the ERS in myocardial tissue of heart failure after myocardial infarction and CHOP and caspase-12 apoptotic signaling pathway, upregulating Bcl-2/Bax expression and downregulating caspase-3 expression, thus inhibiting the cardiac remodeling and protecting the cardiac function." @default.
• W2857071096 created "2018-07-19" @default.
• W2857071096 creator A5019925430 @default.
• W2857071096 creator A5038260854 @default.
• W2857071096 creator A5045138056 @default.
• W2857071096 creator A5054425698 @default.
• W2857071096 creator A5060485719 @default.
• W2857071096 creator A5061333897 @default.
• W2857071096 creator A5073468135 @default.
• W2857071096 creator A5083841661 @default.
• W2857071096 creator A5090986992 @default.
• W2857071096 date "2018-07-11" @default.
• W2857071096 modified "2023-09-25" @default.
• W2857071096 title "Berberine inhibits cardiac remodeling of heart failure after myocardial infarction by reducing myocardial cell apoptosis in rats" @default.
• W2857071096 cites W1484672549 @default.
• W2857071096 cites W1614956991 @default.
• W2857071096 cites W1766341056 @default.
• W2857071096 cites W1775255718 @default.
• W2857071096 cites W1911911263 @default.
• W2857071096 cites W1992765014 @default.
• W2857071096 cites W1998154808 @default.
• W2857071096 cites W2000587163 @default.
• W2857071096 cites W2044452441 @default.
• W2857071096 cites W2054165882 @default.
• W2857071096 cites W2064569332 @default.
• W2857071096 cites W2110906735 @default.
• W2857071096 cites W2129300620 @default.
• W2857071096 cites W2132293802 @default.
• W2857071096 cites W2138548325 @default.
• W2857071096 cites W2220890761 @default.
• W2857071096 cites W2227964848 @default.
• W2857071096 cites W2256965366 @default.
• W2857071096 cites W2273871076 @default.
• W2857071096 cites W2415615619 @default.
• W2857071096 cites W2460146950 @default.
• W2857071096 cites W2467316001 @default.
• W2857071096 cites W2509440351 @default.
• W2857071096 cites W2517160621 @default.
• W2857071096 cites W2531361274 @default.
• W2857071096 cites W2782168943 @default.
• W2857071096 cites W884442819 @default.
• W2857071096 doi "https://doi.org/10.3892/etm.2018.6438" @default.
• W2857071096 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6122433" @default.
• W2857071096 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30186485" @default.
• W2857071096 hasPublicationYear "2018" @default.
• W2857071096 type Work @default.
• W2857071096 sameAs 2857071096 @default.
• W2857071096 citedByCount "13" @default.
• W2857071096 countsByYear W28570710962019 @default.
• W2857071096 countsByYear W28570710962020 @default.
• W2857071096 countsByYear W28570710962021 @default.
• W2857071096 countsByYear W28570710962022 @default.
• W2857071096 countsByYear W28570710962023 @default.
• W2857071096 crossrefType "journal-article" @default.
• W2857071096 hasAuthorship W2857071096A5019925430 @default.
• W2857071096 hasAuthorship W2857071096A5038260854 @default.
• W2857071096 hasAuthorship W2857071096A5045138056 @default.
• W2857071096 hasAuthorship W2857071096A5054425698 @default.
• W2857071096 hasAuthorship W2857071096A5060485719 @default.
• W2857071096 hasAuthorship W2857071096A5061333897 @default.
• W2857071096 hasAuthorship W2857071096A5073468135 @default.
• W2857071096 hasAuthorship W2857071096A5083841661 @default.
• W2857071096 hasAuthorship W2857071096A5090986992 @default.
• W2857071096 hasBestOaLocation W28570710961 @default.
• W2857071096 hasConcept C111566952 @default.
• W2857071096 hasConcept C126322002 @default.
• W2857071096 hasConcept C164705383 @default.
• W2857071096 hasConcept C190283241 @default.
• W2857071096 hasConcept C2776694085 @default.
• W2857071096 hasConcept C2777798775 @default.
• W2857071096 hasConcept C2778198053 @default.
• W2857071096 hasConcept C2779537366 @default.
• W2857071096 hasConcept C2779725641 @default.
• W2857071096 hasConcept C2780116568 @default.
• W2857071096 hasConcept C3018763269 @default.
• W2857071096 hasConcept C500558357 @default.
• W2857071096 hasConcept C55493867 @default.
• W2857071096 hasConcept C71924100 @default.
• W2857071096 hasConcept C86803240 @default.
• W2857071096 hasConcept C98274493 @default.
• W2857071096 hasConceptScore W2857071096C111566952 @default.
• W2857071096 hasConceptScore W2857071096C126322002 @default.
• W2857071096 hasConceptScore W2857071096C164705383 @default.
• W2857071096 hasConceptScore W2857071096C190283241 @default.
• W2857071096 hasConceptScore W2857071096C2776694085 @default.
• W2857071096 hasConceptScore W2857071096C2777798775 @default.
• W2857071096 hasConceptScore W2857071096C2778198053 @default.
• W2857071096 hasConceptScore W2857071096C2779537366 @default.
• W2857071096 hasConceptScore W2857071096C2779725641 @default.
• W2857071096 hasConceptScore W2857071096C2780116568 @default.
• W2857071096 hasConceptScore W2857071096C3018763269 @default.
• W2857071096 hasConceptScore W2857071096C500558357 @default.
• W2857071096 hasConceptScore W2857071096C55493867 @default.
• W2857071096 hasConceptScore W2857071096C71924100 @default.
• W2857071096 hasConceptScore W2857071096C86803240 @default.
• W2857071096 hasConceptScore W2857071096C98274493 @default.
• W2857071096 hasLocation W28570710961 @default.
• W2857071096 hasLocation W28570710962 @default.
• W2857071096 hasLocation W28570710963 @default.
• W2857071096 hasLocation W28570710964 @default.

• next