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- W2857142422 abstract "In order to probe the roles of PIP2 in the interactions between MIM I-BAR and model membranes, we performed a series of 10 μs-scale coarse-grained molecular dynamics simulations. Our results indicate that PIP2 plays predominant roles in the membrane binding of MIM I-BAR in a concentration-dependent manner and via electrostatic interactions. Besides, we find that the occurrence of the membrane curvature may induce the re-distribution of lipids in the membrane and result in the local enrichment of PIP2 at negatively curved membrane areas. Combining these roles of PIP2 in the membrane binding of MIM I-BAR helps explain how MIM I-BAR senses negative curvature and, thus, contributes to maintaining membrane protrusions." @default.
- W2857142422 created "2018-07-19" @default.
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- W2857142422 date "2018-07-26" @default.
- W2857142422 modified "2023-10-16" @default.
- W2857142422 title "Roles of <scp>PIP</scp> 2 in the membrane binding of <scp>MIM</scp> I‐ <scp>BAR</scp> : insights from molecular dynamics simulations" @default.
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- W2857142422 doi "https://doi.org/10.1002/1873-3468.13186" @default.
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