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- W285758932 abstract "The relation between elevated plasma cholesterol levels and risk for coronary heart disease (CHD) has been established by numerous large-scale epidemiological trials [1]. Several clinical trials have firmly established that aggressive manipulation and normalization of elevated total and low-density lipoprotein (LDL) cholesterol by pharmacological means reduce both the progression of atherosclerosis and the incidence of coronary events [2–4]. A number of cholesterol lowering drugs are currently available for human use [2,5]. In the last decade, a new class of agents which specifically inhibits 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase, the rate limiting enzyme in cholesterol biosynthesis, has been developed [6]. Six HMG-CoA reductase inhibitors (statins) are available for clinical use: lovastatin, cerivastatin, pravastatin, simvastatin, atorvastatin, and fluvastatin [7–11]. The available clinical data for HMG-CoA reductase inhibitors demonstrate their efficacy and safety in treating hypercholesterolemia and improving long-term morbidity and mortality related to CHD [12]. It has been assumed that, in atherosclerotic patients, any beneficial effect of statins is linked to their hypolipidemic properties, suggesting that this is the main mechanism for preventing the development of atherosclerosis [13,14]." @default.
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- W285758932 date "1998-01-01" @default.
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- W285758932 title "Effect of Statins Beyond Lowering Cholesterol: Where Do We Stand?" @default.
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- W285758932 doi "https://doi.org/10.1007/978-94-011-5022-4_30" @default.
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