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- W285776427 abstract "Organofluorine compounds have unique physicochemical properties such as enhanced chemical, thermal, and metabolic stability; bioavailability; and membrane permeability, and are widely used components of materials, agrochemical, and pharmaceuticals. Although the effect of fluorine is not completely predictable, strategically fluorinated pharmaceutical compounds often show enhanced binding affinity to the active sites of enzymes, and the fluorinated pharmaceuticals or drug candidates have relatively improved oxidative and metabolic stability, as exemplified by the widely used pharmaceuticals such as celecoxib, ciprofloxacin, and ezetimibe. Due to its high sensitivity, wide chemical shift range, and absence of background 19F signals, 19F nuclear magnetic resonance (NMR) is ideally suited for monitoring the biochemical reaction mechanisms and in the design of drug candidates. The rapid and convenient 19F NMR-based screening of fluorinated drug candidates, which is based on their relative binding affinity to the enzymes, would lead to the development of novel and more effective therapeutics. This chapter summarizes the unique physicochemical properties of fluorinated compounds relevant to drug design, and for probing biochemical mechanisms." @default.
- W285776427 created "2016-06-24" @default.
- W285776427 creator A5016912396 @default.
- W285776427 date "2015-01-01" @default.
- W285776427 modified "2023-10-18" @default.
- W285776427 title "General Aspects of Organofluorine Compounds" @default.
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- W285776427 doi "https://doi.org/10.1016/b978-0-444-53748-5.00001-0" @default.
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