FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2858013578> ?p ?o ?g. }

• W2858013578 abstract "DNA methylation is a heritable epigenetic mark, enabling stable but reversible gene repression. In mammalian cells, DNA methyltransferases (DNMTs) are responsible for modifying cytosine to 5-methylcytosine (5mC), which can be further oxidized by the TET dioxygenases to ultimately cause DNA demethylation. However, the genome-wide cooperation and functions of these two families of proteins, especially at large under-methylated regions, called canyons, remain largely unknown.Here we demonstrate that DNMT3A and TET1 function in a complementary and competitive manner in mouse embryonic stem cells to mediate proper epigenetic landscapes and gene expression. The longer isoform of DNMT3A, DNMT3A1, exhibits significant enrichment at distal promoters and canyon edges, but is excluded from proximal promoters and canyons where TET1 shows prominent binding. Deletion of Tet1 increases DNMT3A1 binding capacity at and around genes with wild-type TET1 binding. However, deletion of Dnmt3a has a minor effect on TET1 binding on chromatin, indicating that TET1 may limit DNA methylation partially by protecting its targets from DNMT3A and establishing boundaries for DNA methylation. Local CpG density may determine their complementary binding patterns and therefore that the methylation landscape is encoded in the DNA sequence. Furthermore, DNMT3A and TET1 impact histone modifications which in turn regulate gene expression. In particular, they regulate Polycomb Repressive Complex 2 (PRC2)-mediated H3K27me3 enrichment to constrain gene expression from bivalent promoters.We conclude that DNMT3A and TET1 regulate the epigenome and gene expression at specific targets via their functional interplay." @default.
• W2858013578 created "2018-07-19" @default.
• W2858013578 creator A5009068819 @default.
• W2858013578 creator A5022116606 @default.
• W2858013578 creator A5027044461 @default.
• W2858013578 creator A5030075242 @default.
• W2858013578 creator A5036633061 @default.
• W2858013578 creator A5037301722 @default.
• W2858013578 creator A5038515348 @default.
• W2858013578 creator A5039864753 @default.
• W2858013578 creator A5044336968 @default.
• W2858013578 creator A5048350024 @default.
• W2858013578 creator A5052198607 @default.
• W2858013578 creator A5058149977 @default.
• W2858013578 creator A5065271113 @default.
• W2858013578 creator A5068486677 @default.
• W2858013578 creator A5072707191 @default.
• W2858013578 creator A5074463940 @default.
• W2858013578 creator A5077198827 @default.
• W2858013578 creator A5083159278 @default.
• W2858013578 creator A5083993271 @default.
• W2858013578 creator A5088202206 @default.
• W2858013578 date "2018-07-12" @default.
• W2858013578 modified "2023-10-14" @default.
• W2858013578 title "DNMT3A and TET1 cooperate to regulate promoter epigenetic landscapes in mouse embryonic stem cells" @default.
• W2858013578 cites W1850661934 @default.
• W2858013578 cites W1968717432 @default.
• W2858013578 cites W1968931043 @default.
• W2858013578 cites W1976573435 @default.
• W2858013578 cites W1981463058 @default.
• W2858013578 cites W1988704296 @default.
• W2858013578 cites W1997453048 @default.
• W2858013578 cites W2014623973 @default.
• W2858013578 cites W2015493376 @default.
• W2858013578 cites W2017515560 @default.
• W2858013578 cites W2020016210 @default.
• W2858013578 cites W2030687162 @default.
• W2858013578 cites W2036832665 @default.
• W2858013578 cites W2038449573 @default.
• W2858013578 cites W2040795628 @default.
• W2858013578 cites W2046241907 @default.
• W2858013578 cites W2057089696 @default.
• W2858013578 cites W2058184727 @default.
• W2858013578 cites W2060446375 @default.
• W2858013578 cites W2063007091 @default.
• W2858013578 cites W2076840637 @default.
• W2858013578 cites W2077359452 @default.
• W2858013578 cites W2083536957 @default.
• W2858013578 cites W2084203180 @default.
• W2858013578 cites W2088708165 @default.
• W2858013578 cites W2092116145 @default.
• W2858013578 cites W2095881412 @default.
• W2858013578 cites W2097324844 @default.
• W2858013578 cites W2100305481 @default.
• W2858013578 cites W2103441770 @default.
• W2858013578 cites W2106889224 @default.
• W2858013578 cites W2107024719 @default.
• W2858013578 cites W2108234281 @default.
• W2858013578 cites W2108664872 @default.
• W2858013578 cites W2116816603 @default.
• W2858013578 cites W2117961940 @default.
• W2858013578 cites W2121475945 @default.
• W2858013578 cites W2124985265 @default.
• W2858013578 cites W2131034808 @default.
• W2858013578 cites W2136079563 @default.
• W2858013578 cites W2145534945 @default.
• W2858013578 cites W2149790281 @default.
• W2858013578 cites W2157232603 @default.
• W2858013578 cites W2161224111 @default.
• W2858013578 cites W2170039745 @default.
• W2858013578 cites W2171808845 @default.
• W2858013578 cites W2188223075 @default.
• W2858013578 cites W2487895297 @default.
• W2858013578 cites W2498404744 @default.
• W2858013578 cites W2525877111 @default.
• W2858013578 cites W2532812479 @default.
• W2858013578 cites W2553076365 @default.
• W2858013578 cites W2766643978 @default.
• W2858013578 cites W4245544344 @default.
• W2858013578 doi "https://doi.org/10.1186/s13059-018-1464-7" @default.
• W2858013578 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6042404" @default.
• W2858013578 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30001199" @default.
• W2858013578 hasPublicationYear "2018" @default.
• W2858013578 type Work @default.
• W2858013578 sameAs 2858013578 @default.
• W2858013578 citedByCount "108" @default.
• W2858013578 countsByYear W28580135782018 @default.
• W2858013578 countsByYear W28580135782019 @default.
• W2858013578 countsByYear W28580135782020 @default.
• W2858013578 countsByYear W28580135782021 @default.
• W2858013578 countsByYear W28580135782022 @default.
• W2858013578 countsByYear W28580135782023 @default.
• W2858013578 crossrefType "journal-article" @default.
• W2858013578 hasAuthorship W2858013578A5009068819 @default.
• W2858013578 hasAuthorship W2858013578A5022116606 @default.
• W2858013578 hasAuthorship W2858013578A5027044461 @default.
• W2858013578 hasAuthorship W2858013578A5030075242 @default.
• W2858013578 hasAuthorship W2858013578A5036633061 @default.
• W2858013578 hasAuthorship W2858013578A5037301722 @default.
• W2858013578 hasAuthorship W2858013578A5038515348 @default.

• next