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• W2858352068 abstract "Protein-RNA recognition often induces conformational changes in binding partners. Consequently, the solvent accessible surface area (SASA) buried in contact estimated from the co-crystal structures may differ from that calculated using their unbound forms. To evaluate the change in accessibility upon binding, we compare SASA of 126 protein-RNA complexes between bound and unbound forms. We observe, in majority of cases the interface of both the binding partners gain accessibility upon binding, which is often associated with either large domain movements or secondary structural transitions in RNA-binding proteins (RBPs), and binding-induced conformational changes in RNAs. At the non-interface region, majority of RNAs lose accessibility upon binding, however, no such preference is observed for RBPs. Side chains of RBPs have major contribution in change in accessibility. In case of flexible binding, we find a moderate correlation between the binding free energy and change in accessibility at the interface. Finally, we introduce a parameter, the ratio of gain to loss of accessibility upon binding, which can be used to identify the native solution among the flexible docking models. Our findings provide fundamental insights into the relationship between flexibility and solvent accessibility, and advance our understanding on binding induced folding in protein-RNA recognition." @default.
• W2858352068 created "2018-07-19" @default.
• W2858352068 creator A5012819664 @default.
• W2858352068 creator A5047641571 @default.
• W2858352068 date "2018-07-12" @default.
• W2858352068 modified "2023-10-16" @default.
• W2858352068 title "An account of solvent accessibility in protein-RNA recognition" @default.
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• W2858352068 doi "https://doi.org/10.1038/s41598-018-28373-2" @default.
• W2858352068 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6043566" @default.
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• W2858352068 hasPublicationYear "2018" @default.
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