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- W285963485 abstract "We aimed to investigate mitochondrial function, biogenesis and autophagy in the brain of type 2 diabetes (T2D) and Alzheimer's disease (AD) mice. Isolated brain mitochondria and homogenates from cerebral cortex and hippocampus of wild-type (WT), triple transgenic AD (3xTg-AD) and T2D mice were used to evaluate mitochondrial functional parameters and protein levels of mitochondrial biogenesis, autophagy and synaptic integrity markers, respectively. A significant decrease in mitochondrial respiration, membrane potential and energy levels was observed in T2D and 3xTg-AD mice. Also, a significant decrease in the levels of autophagy-related protein 7 (ATG7) and glycosylated lysosomal membrane protein 1 (LAMP1) was observed in cerebral cortex and hippocampus of T2D and 3xTg-AD mice. Moreover, both brain regions of 3xTg-AD mice present lower levels of nuclear respiratory factor (NRF) 1 while the levels of NRF2 are lower in both brain regions of T2D and 3xTg-AD mice. A decrease in mitochondrial encoded, nicotinamide adenine dinucleotide dehydrogenase subunit 1 (ND1) was also observed in T2D and 3xTg-AD mice although only statistically significant in T2D cortex. Furthermore, a decrease in the levels of postsynaptic density protein 95 (PSD95) in the cerebral cortex of 3xTg-AD mice and in hippocampus of T2D and 3xTg-AD mice and a decrease in the levels of synaptosomal-associated protein 25 (SNAP 25) in the hippocampus of T2D and 3xTg-AD mice were observed suggesting synaptic integrity loss. These results support the idea that alterations in mitochondrial function, biogenesis and autophagy cause synaptic damage in AD and T2D." @default.
- W285963485 created "2016-06-24" @default.
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- W285963485 creator A5053059798 @default.
- W285963485 creator A5058867273 @default.
- W285963485 date "2015-08-01" @default.
- W285963485 modified "2023-09-30" @default.
- W285963485 title "Alzheimer's disease and type 2 diabetes-related alterations in brain mitochondria, autophagy and synaptic markers" @default.
- W285963485 cites W1506043065 @default.
- W285963485 cites W1546896514 @default.
- W285963485 cites W1883048423 @default.
- W285963485 cites W1919353 @default.
- W285963485 cites W1921013807 @default.
- W285963485 cites W1966191258 @default.
- W285963485 cites W1966558304 @default.
- W285963485 cites W1967464880 @default.
- W285963485 cites W1975391137 @default.
- W285963485 cites W1977897455 @default.
- W285963485 cites W1982021390 @default.
- W285963485 cites W1982182604 @default.
- W285963485 cites W1985612355 @default.
- W285963485 cites W1987254708 @default.
- W285963485 cites W1994823455 @default.
- W285963485 cites W1999333769 @default.
- W285963485 cites W2000966665 @default.
- W285963485 cites W2006840724 @default.
- W285963485 cites W2007472466 @default.
- W285963485 cites W2007743440 @default.
- W285963485 cites W2008205111 @default.
- W285963485 cites W2008958059 @default.
- W285963485 cites W2014506057 @default.
- W285963485 cites W2017865400 @default.
- W285963485 cites W2018427433 @default.
- W285963485 cites W2024267786 @default.
- W285963485 cites W2029308011 @default.
- W285963485 cites W2033603289 @default.
- W285963485 cites W2034257150 @default.
- W285963485 cites W2034388777 @default.
- W285963485 cites W2034888251 @default.
- W285963485 cites W2036464358 @default.
- W285963485 cites W2037653131 @default.
- W285963485 cites W2038049117 @default.
- W285963485 cites W2047227316 @default.
- W285963485 cites W2049599293 @default.
- W285963485 cites W2049804246 @default.
- W285963485 cites W2052406949 @default.
- W285963485 cites W2053053005 @default.
- W285963485 cites W2069037616 @default.
- W285963485 cites W2071186135 @default.
- W285963485 cites W2072595318 @default.
- W285963485 cites W2073644281 @default.
- W285963485 cites W2076914779 @default.
- W285963485 cites W2080375658 @default.
- W285963485 cites W2081706292 @default.
- W285963485 cites W2082411508 @default.
- W285963485 cites W2083908392 @default.
- W285963485 cites W2084762017 @default.
- W285963485 cites W2088514099 @default.
- W285963485 cites W2089616240 @default.
- W285963485 cites W2089936534 @default.
- W285963485 cites W2090409064 @default.
- W285963485 cites W2092320787 @default.
- W285963485 cites W2094924105 @default.
- W285963485 cites W2098548022 @default.
- W285963485 cites W2117176621 @default.
- W285963485 cites W2121830778 @default.
- W285963485 cites W2123201941 @default.
- W285963485 cites W2124813430 @default.
- W285963485 cites W2128537698 @default.
- W285963485 cites W2133153589 @default.
- W285963485 cites W2135224381 @default.
- W285963485 cites W2136916247 @default.
- W285963485 cites W2139941678 @default.
- W285963485 cites W2140751228 @default.
- W285963485 cites W2146887271 @default.
- W285963485 cites W2148391873 @default.
- W285963485 cites W2149249593 @default.
- W285963485 cites W2150713795 @default.
- W285963485 cites W2153281726 @default.
- W285963485 cites W2154104081 @default.
- W285963485 cites W2164367561 @default.
- W285963485 cites W2165427528 @default.
- W285963485 cites W2167115031 @default.
- W285963485 cites W2323812523 @default.
- W285963485 doi "https://doi.org/10.1016/j.bbadis.2015.05.001" @default.
- W285963485 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25960150" @default.
- W285963485 hasPublicationYear "2015" @default.
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