FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2859728640> ?p ?o ?g. }

• W2859728640 endingPage "122" @default.
• W2859728640 startingPage "112" @default.
• W2859728640 abstract "The aim of this study was to prepare fluconazole (FLC) nanoparticles coated with polyethylene glycol (PEG) in the form of FLC-PEG-NPs and optimize the size and entrapment efficiency. Nine formulae were prepared by solvent antisolvent precipitation technique according to full 32 factorial designs. The effects of PEG molecular weight (X1) and the drug polymer ratio (X2) on the particle size (Y1) and entrapment efficiency (Y2) were explored. The prepared FLC-PEG-NPs were investigated for particle size, count rate, PDI, zeta potential, and morphology. Carbopol hydrogel was prepared, loaded with optimized FLC-PEG-NPs, and characterized for pH, FLC content, viscosity, homogeneity and spreadability, in vitro release, skin permeation, and antifungal activity. The formulated nanoparticles were uniform in size and spherical in shape with slightly rough surface and free from aggregations. The effect of PEG molecular was antagonistic on the particle size and was agonistic on EE %. The release of drug from hydrogel containing pure FLC was always lower than that from hydrogel containing FLC-PEG-NPs. The kinetic analysis of drug release obeys first-order release model and super case II transport mechanism. The cumulative amount of drug permeated applying hydrogel containing optimized FLC-PEG-NPs was significantly higher than the amount permeated using pure fluconazole containing hydrogel. The antifungal activity of hydrogel containing FLC in the form of optimized PEG-coated nanoparticles was better than hydrogel containing pure drug as indicated by relatively high inhibition zone using agar well-diffusion method. Small spherical FLC nanoparticles with enhanced in vitro drug release as well as improved antifungal activity could be achieved by using PEG-coated fluconazole nanoparticles." @default.
• W2859728640 created "2018-07-19" @default.
• W2859728640 creator A5023260733 @default.
• W2859728640 creator A5061654385 @default.
• W2859728640 creator A5080195353 @default.
• W2859728640 creator A5086725953 @default.
• W2859728640 date "2018-07-06" @default.
• W2859728640 modified "2023-10-10" @default.
• W2859728640 title "Hydrogel Containing PEG-Coated Fluconazole Nanoparticles with Enhanced Solubility and Antifungal Activity" @default.
• W2859728640 cites W1972913560 @default.
• W2859728640 cites W1975505033 @default.
• W2859728640 cites W2003404001 @default.
• W2859728640 cites W2042625404 @default.
• W2859728640 cites W2044398062 @default.
• W2859728640 cites W2071599171 @default.
• W2859728640 cites W2081872487 @default.
• W2859728640 cites W2093326728 @default.
• W2859728640 cites W2154348187 @default.
• W2859728640 cites W2186693569 @default.
• W2859728640 cites W2198343570 @default.
• W2859728640 cites W2288283009 @default.
• W2859728640 cites W2323622792 @default.
• W2859728640 cites W2325242823 @default.
• W2859728640 cites W2402319960 @default.
• W2859728640 cites W2506109233 @default.
• W2859728640 cites W2601162940 @default.
• W2859728640 cites W2768839005 @default.
• W2859728640 cites W2774577296 @default.
• W2859728640 doi "https://doi.org/10.1007/s12247-018-9335-z" @default.
• W2859728640 hasPublicationYear "2018" @default.
• W2859728640 type Work @default.
• W2859728640 sameAs 2859728640 @default.
• W2859728640 citedByCount "26" @default.
• W2859728640 countsByYear W28597286402019 @default.
• W2859728640 countsByYear W28597286402020 @default.
• W2859728640 countsByYear W28597286402021 @default.
• W2859728640 countsByYear W28597286402022 @default.
• W2859728640 countsByYear W28597286402023 @default.
• W2859728640 crossrefType "journal-article" @default.
• W2859728640 hasAuthorship W2859728640A5023260733 @default.
• W2859728640 hasAuthorship W2859728640A5061654385 @default.
• W2859728640 hasAuthorship W2859728640A5080195353 @default.
• W2859728640 hasAuthorship W2859728640A5086725953 @default.
• W2859728640 hasBestOaLocation W28597286401 @default.
• W2859728640 hasConcept C10138342 @default.
• W2859728640 hasConcept C127413603 @default.
• W2859728640 hasConcept C13965031 @default.
• W2859728640 hasConcept C155574463 @default.
• W2859728640 hasConcept C155672457 @default.
• W2859728640 hasConcept C16005928 @default.
• W2859728640 hasConcept C162324750 @default.
• W2859728640 hasConcept C171250308 @default.
• W2859728640 hasConcept C178790620 @default.
• W2859728640 hasConcept C185592680 @default.
• W2859728640 hasConcept C187530423 @default.
• W2859728640 hasConcept C192562407 @default.
• W2859728640 hasConcept C2776964284 @default.
• W2859728640 hasConcept C2779548794 @default.
• W2859728640 hasConcept C2991737395 @default.
• W2859728640 hasConcept C41625074 @default.
• W2859728640 hasConcept C42360764 @default.
• W2859728640 hasConcept C43617362 @default.
• W2859728640 hasConcept C50670333 @default.
• W2859728640 hasConcept C521977710 @default.
• W2859728640 hasConcept C54400483 @default.
• W2859728640 hasConcept C55493867 @default.
• W2859728640 hasConcept C71924100 @default.
• W2859728640 hasConcept C86181022 @default.
• W2859728640 hasConcept C88380143 @default.
• W2859728640 hasConceptScore W2859728640C10138342 @default.
• W2859728640 hasConceptScore W2859728640C127413603 @default.
• W2859728640 hasConceptScore W2859728640C13965031 @default.
• W2859728640 hasConceptScore W2859728640C155574463 @default.
• W2859728640 hasConceptScore W2859728640C155672457 @default.
• W2859728640 hasConceptScore W2859728640C16005928 @default.
• W2859728640 hasConceptScore W2859728640C162324750 @default.
• W2859728640 hasConceptScore W2859728640C171250308 @default.
• W2859728640 hasConceptScore W2859728640C178790620 @default.
• W2859728640 hasConceptScore W2859728640C185592680 @default.
• W2859728640 hasConceptScore W2859728640C187530423 @default.
• W2859728640 hasConceptScore W2859728640C192562407 @default.
• W2859728640 hasConceptScore W2859728640C2776964284 @default.
• W2859728640 hasConceptScore W2859728640C2779548794 @default.
• W2859728640 hasConceptScore W2859728640C2991737395 @default.
• W2859728640 hasConceptScore W2859728640C41625074 @default.
• W2859728640 hasConceptScore W2859728640C42360764 @default.
• W2859728640 hasConceptScore W2859728640C43617362 @default.
• W2859728640 hasConceptScore W2859728640C50670333 @default.
• W2859728640 hasConceptScore W2859728640C521977710 @default.
• W2859728640 hasConceptScore W2859728640C54400483 @default.
• W2859728640 hasConceptScore W2859728640C55493867 @default.
• W2859728640 hasConceptScore W2859728640C71924100 @default.
• W2859728640 hasConceptScore W2859728640C86181022 @default.
• W2859728640 hasConceptScore W2859728640C88380143 @default.
• W2859728640 hasIssue "2" @default.
• W2859728640 hasLocation W28597286401 @default.
• W2859728640 hasOpenAccess W2859728640 @default.
• W2859728640 hasPrimaryLocation W28597286401 @default.

• next