Matches in SemOpenAlex for { <https://semopenalex.org/work/W285985340> ?p ?o ?g. }
- W285985340 endingPage "561" @default.
- W285985340 startingPage "511" @default.
- W285985340 abstract "Almost all eukaryotic mRNAs have a monomethylguanosine cap structure consisting of 7-methyl guanosine that is connected via 5′–5′ triphosphate bond to the next nucleoside (m7GpppN; MMG-cap) on their 5′ termini. In unicellular kinetoplastida, including Leishmanias (responsible for a wide spectrum of diseases), the cap is unusually highly methylated (m7Gpppm3 6,6,2′Apm2′Apm2′Cpm2 3,2′U), known as cap-4, while in nematodes (e.g., C. elegans or Ascaris), the mRNA cap is ended with trimethylguanosine (m3 2,2,7GpppN; TMG-cap). A large class of uridine-rich small nuclear RNAs (U snRNAs) on their 5′ termini have also TMG-cap. Over the last three decades several classes of 5′ mRNA cap analogs, including the natural ones (MMG-cap, TMG-cap, cap-4), have been synthesized in our lab and by other groups. They were serving as valuable tools in elucidating molecular mechanisms of such cap-regulated cellular processes as protein translation initiation, pre-mRNA splicing, RNA intracellular transport, mRNA turnover, and cap-dependent translation inhibition by microRNAs. Some of the synthetic cap dinucleotides (anti-reverse cap analogs; ARCAs), adopted to construct mRNA transcripts with the increased translational efficiency, have found commercial application in production of proteins. In this chapter, we describe the strategies and technical approaches in the synthesis of natural and modified cap analogs. Their application in biology and more recently, in medical studies is also reviewed." @default.
- W285985340 created "2016-06-24" @default.
- W285985340 creator A5076867281 @default.
- W285985340 creator A5085621206 @default.
- W285985340 date "2014-01-01" @default.
- W285985340 modified "2023-10-16" @default.
- W285985340 title "mRNA and snRNA Cap Analogs: Synthesis and Applications" @default.
- W285985340 cites W1483270268 @default.
- W285985340 cites W1520611165 @default.
- W285985340 cites W1531431054 @default.
- W285985340 cites W1545552681 @default.
- W285985340 cites W1546346940 @default.
- W285985340 cites W1580569367 @default.
- W285985340 cites W1593615758 @default.
- W285985340 cites W1603778040 @default.
- W285985340 cites W160384131 @default.
- W285985340 cites W1639795491 @default.
- W285985340 cites W1966386635 @default.
- W285985340 cites W1966783412 @default.
- W285985340 cites W1967273961 @default.
- W285985340 cites W1968919723 @default.
- W285985340 cites W1969185977 @default.
- W285985340 cites W1969353028 @default.
- W285985340 cites W1970860709 @default.
- W285985340 cites W1971529523 @default.
- W285985340 cites W1973122645 @default.
- W285985340 cites W1974280022 @default.
- W285985340 cites W1974456887 @default.
- W285985340 cites W1975815147 @default.
- W285985340 cites W1976118264 @default.
- W285985340 cites W1976456179 @default.
- W285985340 cites W1978091886 @default.
- W285985340 cites W1979269225 @default.
- W285985340 cites W1979948097 @default.
- W285985340 cites W1985552502 @default.
- W285985340 cites W1986406328 @default.
- W285985340 cites W1986565004 @default.
- W285985340 cites W1988640094 @default.
- W285985340 cites W1990404580 @default.
- W285985340 cites W1991884238 @default.
- W285985340 cites W1992508643 @default.
- W285985340 cites W1992965147 @default.
- W285985340 cites W1994163832 @default.
- W285985340 cites W1995875994 @default.
- W285985340 cites W1998225437 @default.
- W285985340 cites W1998892433 @default.
- W285985340 cites W1998967295 @default.
- W285985340 cites W1999776725 @default.
- W285985340 cites W1999950622 @default.
- W285985340 cites W2000535837 @default.
- W285985340 cites W2001127325 @default.
- W285985340 cites W2001369160 @default.
- W285985340 cites W2001874268 @default.
- W285985340 cites W2001988280 @default.
- W285985340 cites W2004352744 @default.
- W285985340 cites W2004726791 @default.
- W285985340 cites W2005404486 @default.
- W285985340 cites W2006691081 @default.
- W285985340 cites W2008052485 @default.
- W285985340 cites W2008817826 @default.
- W285985340 cites W2010289671 @default.
- W285985340 cites W2011961482 @default.
- W285985340 cites W2012832094 @default.
- W285985340 cites W2013328509 @default.
- W285985340 cites W2013428743 @default.
- W285985340 cites W2014886844 @default.
- W285985340 cites W2015532290 @default.
- W285985340 cites W2018842647 @default.
- W285985340 cites W2019665262 @default.
- W285985340 cites W2020889498 @default.
- W285985340 cites W2020895445 @default.
- W285985340 cites W2021310851 @default.
- W285985340 cites W2022302833 @default.
- W285985340 cites W2022356649 @default.
- W285985340 cites W2023176508 @default.
- W285985340 cites W2023348412 @default.
- W285985340 cites W2023728920 @default.
- W285985340 cites W2025799813 @default.
- W285985340 cites W2028594105 @default.
- W285985340 cites W2028691640 @default.
- W285985340 cites W2029396826 @default.
- W285985340 cites W2029748625 @default.
- W285985340 cites W2033246082 @default.
- W285985340 cites W2036426257 @default.
- W285985340 cites W2037313242 @default.
- W285985340 cites W2037326045 @default.
- W285985340 cites W2037733820 @default.
- W285985340 cites W2039258463 @default.
- W285985340 cites W2039867172 @default.
- W285985340 cites W2040174498 @default.
- W285985340 cites W2040579733 @default.
- W285985340 cites W2041737219 @default.
- W285985340 cites W2042097494 @default.
- W285985340 cites W2043059870 @default.
- W285985340 cites W2044980847 @default.
- W285985340 cites W2046518996 @default.
- W285985340 cites W2047295144 @default.
- W285985340 cites W2047627934 @default.