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• W2860443571 abstract "Efficacy and safety of Ginkgo biloba extract as an add-on treatment to metformin for patients with metabolic syndrome: a pilot clinical study Tavga Ahmed Aziz,1 Saad Abdulrahman Hussain,2 Taha Othman Mahwi,3 Zheen Aorahman Ahmed1 1Department of Pharmacology and Toxicology, College of Pharmacy, University of Sulaimani, Kurdistan, Iraq; 2Department of Pharmacology and Toxicology, Faculty of Pharmacy, Al-Rafidain University College, Baghdad, Iraq; 3Department of Internal Medicine, College of Medicine, University of Sulaimani, Kurdistan, Iraq Background and aim: Ginkgo biloba (GKB) extract has shown to be beneficial in experimental models of metabolic and inflammatory disorders such as diabetes and metabolic syndrome (MTS). The objective of this pilot clinical study was to evaluate the effects of GKB extract as an “add-on” treatment with metformin (Met) in MTS patients. Patients and methods: We performed a randomized, placebo-controlled, double-blinded clinical study in subjects with MTS. Forty patients completed the 90-day clinical trial and were randomly allocated to administer either GKB extract (120 mg capsule/day) or placebo (120 mg starch/day) as an add-on treatment with their currently used doses of Met for 90 days. During the study, body mass index (BMI), waist circumference (WC), serum leptin, glycated hemoglobin (HbA1c), fasting serum glucose (FSG), insulin, insulin resistance (IR), visceral adiposity index (VAI), lipid profile, and the inflammatory markers high sensitive C-reactive protein (hsCRP), tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6) were evaluated. Results: GKB extract significantly decreases HbA1c, FSG and insulin levels, IR, BMI, WC, VAI, serum leptin, and the inflammatory markers compared to baseline values. Simultaneously, GKB did not negatively affect the functions of the liver, kidney, and hematopoietic system. Conclusion: The use of GKB extract as an adjuvant with Met was effective in improving the outcome of patients with MTS. Keywords: Ginkgo biloba, metabolic syndrome, metformin, adiposity, insulin resistance, inflammation" @default.
• W2860443571 created "2018-07-19" @default.
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• W2860443571 date "2018-07-01" @default.
• W2860443571 modified "2023-09-25" @default.
• W2860443571 title "Efficacy and safety of <em>Ginkgo biloba</em> extract as an &ldquo;add-on&rdquo; treatment to metformin for patients with metabolic syndrome: a pilot clinical study" @default.
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• W2860443571 doi "https://doi.org/10.2147/tcrm.s169503" @default.
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