Matches in SemOpenAlex for { <https://semopenalex.org/work/W2860743873> ?p ?o ?g. }
- W2860743873 endingPage "1256" @default.
- W2860743873 startingPage "1246" @default.
- W2860743873 abstract "Physical function declines in old age, portending disability, increased health expenditures, and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these consequences of aging, but whether senescence can directly drive age-related pathology and be therapeutically targeted is still unclear. Here we demonstrate that transplanting relatively small numbers of senescent cells into young mice is sufficient to cause persistent physical dysfunction, as well as to spread cellular senescence to host tissues. Transplanting even fewer senescent cells had the same effect in older recipients and was accompanied by reduced survival, indicating the potency of senescent cells in shortening health- and lifespan. The senolytic cocktail, dasatinib plus quercetin, which causes selective elimination of senescent cells, decreased the number of naturally occurring senescent cells and their secretion of frailty-related proinflammatory cytokines in explants of human adipose tissue. Moreover, intermittent oral administration of senolytics to both senescent cell–transplanted young mice and naturally aged mice alleviated physical dysfunction and increased post-treatment survival by 36% while reducing mortality hazard to 65%. Our study provides proof-of-concept evidence that senescent cells can cause physical dysfunction and decreased survival even in young mice, while senolytics can enhance remaining health- and lifespan in old mice. Transfer of senescent cells into naive, young mice can induce physical dysfunction, and a senolytic can reverse this dysfunction and potently increase lifespan in aged mice." @default.
- W2860743873 created "2018-07-19" @default.
- W2860743873 creator A5008417669 @default.
- W2860743873 creator A5009102749 @default.
- W2860743873 creator A5010329778 @default.
- W2860743873 creator A5010418551 @default.
- W2860743873 creator A5013458815 @default.
- W2860743873 creator A5014342029 @default.
- W2860743873 creator A5017188043 @default.
- W2860743873 creator A5019981789 @default.
- W2860743873 creator A5026242842 @default.
- W2860743873 creator A5027073303 @default.
- W2860743873 creator A5033246059 @default.
- W2860743873 creator A5034798967 @default.
- W2860743873 creator A5035959642 @default.
- W2860743873 creator A5037636554 @default.
- W2860743873 creator A5040467127 @default.
- W2860743873 creator A5041091292 @default.
- W2860743873 creator A5042220379 @default.
- W2860743873 creator A5045078529 @default.
- W2860743873 creator A5049221943 @default.
- W2860743873 creator A5053037755 @default.
- W2860743873 creator A5060660422 @default.
- W2860743873 creator A5061671539 @default.
- W2860743873 creator A5061894336 @default.
- W2860743873 creator A5062622249 @default.
- W2860743873 creator A5063258499 @default.
- W2860743873 creator A5066152181 @default.
- W2860743873 creator A5066981835 @default.
- W2860743873 creator A5068519051 @default.
- W2860743873 creator A5069851074 @default.
- W2860743873 creator A5072230861 @default.
- W2860743873 creator A5078607845 @default.
- W2860743873 creator A5086992632 @default.
- W2860743873 creator A5088406750 @default.
- W2860743873 date "2018-07-09" @default.
- W2860743873 modified "2023-10-18" @default.
- W2860743873 title "Senolytics improve physical function and increase lifespan in old age" @default.
- W2860743873 cites W1524807258 @default.
- W2860743873 cites W1532716350 @default.
- W2860743873 cites W1545856126 @default.
- W2860743873 cites W1691160266 @default.
- W2860743873 cites W1908141864 @default.
- W2860743873 cites W1932046626 @default.
- W2860743873 cites W1970924670 @default.
- W2860743873 cites W1975412844 @default.
- W2860743873 cites W1990268636 @default.
- W2860743873 cites W1993571663 @default.
- W2860743873 cites W2010417927 @default.
- W2860743873 cites W2024594664 @default.
- W2860743873 cites W2030772730 @default.
- W2860743873 cites W2048101387 @default.
- W2860743873 cites W2049691960 @default.
- W2860743873 cites W2052609811 @default.
- W2860743873 cites W2053289423 @default.
- W2860743873 cites W2054164550 @default.
- W2860743873 cites W2069519394 @default.
- W2860743873 cites W2070507117 @default.
- W2860743873 cites W2091137497 @default.
- W2860743873 cites W2095439262 @default.
- W2860743873 cites W2096587251 @default.
- W2860743873 cites W2097173670 @default.
- W2860743873 cites W2105151699 @default.
- W2860743873 cites W2108887402 @default.
- W2860743873 cites W2109870340 @default.
- W2860743873 cites W2114331328 @default.
- W2860743873 cites W2125764628 @default.
- W2860743873 cites W2128807350 @default.
- W2860743873 cites W2131250713 @default.
- W2860743873 cites W2136253750 @default.
- W2860743873 cites W2140930678 @default.
- W2860743873 cites W2144843569 @default.
- W2860743873 cites W2148537305 @default.
- W2860743873 cites W2149814390 @default.
- W2860743873 cites W2150940840 @default.
- W2860743873 cites W2164059021 @default.
- W2860743873 cites W2191745121 @default.
- W2860743873 cites W2224886002 @default.
- W2860743873 cites W2264758825 @default.
- W2860743873 cites W2266290735 @default.
- W2860743873 cites W2266900518 @default.
- W2860743873 cites W2267907650 @default.
- W2860743873 cites W2273121121 @default.
- W2860743873 cites W2295694318 @default.
- W2860743873 cites W2304048947 @default.
- W2860743873 cites W2341156943 @default.
- W2860743873 cites W2361659253 @default.
- W2860743873 cites W2403936349 @default.
- W2860743873 cites W2467271588 @default.
- W2860743873 cites W2515194864 @default.
- W2860743873 cites W2516117533 @default.
- W2860743873 cites W2516372925 @default.
- W2860743873 cites W2544670169 @default.
- W2860743873 cites W2545605297 @default.
- W2860743873 cites W2575349992 @default.
- W2860743873 cites W2591114726 @default.
- W2860743873 cites W2605674430 @default.
- W2860743873 cites W2620406790 @default.