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- W286076391 abstract "Abstract The yeast Dekkera/Brettanomyces bruxellensis is a distant relative of baker’s yeast Saccharomyces cerevisiae and either has positive or negative effects to beverage flavor development. D. bruxellensis and S. cerevisiae display several similar traits which play very important roles in food industry, such as production of high ethanol levels. In our lab, we determined and annotated the 13.4 Mb genome sequence of the D. bruxellensis strain Y879 (CBS2499) and investigated the genetic background of several “food-relevant” properties of this yeast as well we studied its evolution history and metabolic pathways, such as carbon metabolism. Surprisingly, we found out that D. bruxellensis is closely related to Pichia (Komagataella) pastoris. Interestingly, we only found a low copy number of low affinity sugar transporters in D. bruxellensis. We also studied the main pathway of glucose repression, where Mig1p and Hxk2p play important roles. Just like in S. cerevisiae, the promoters of TCA genes in D. bruxellensis also had many Mig1p binding motifs. Further analysis on aroma related genes showed that the presence of aroma gene duplicates vary among species. However, some of them are duplicated in the species known to have intensive aromatic profile. Finally, the genome sequence of D. bruxellensis was used to build a database employing a special version of Yeast Genome Annotation Pipline (YGAP), a synteny-based pipeline for the automated annotation of yeast genomes. (Less)" @default.
- W286076391 created "2016-06-24" @default.
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- W286076391 date "2012-01-01" @default.
- W286076391 modified "2023-09-27" @default.
- W286076391 title "Genomics of the wine yeast Dekkera bruxellensis" @default.
- W286076391 hasPublicationYear "2012" @default.
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