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- W28608146 abstract "This chapter discusses a common neurological disorder, parkinsonism, and involuntary movement associated with changes in the basal ganglia. The diagnosis of Parkinsonism is clinical and can often be made as soon as the patient is seen, particularly if he or she is observed when walking and does not swing the arms. The clinical features can be grouped under the headings hypokinesia, rigidity, tremor, and loss of associated movements. Parkinson's disease is a progressive disorder, and there is no convincing evidence that the drugs in current use have any influence on the changes in the basal ganglia. The association of systemic hypertension and parkinsonism seems to be uncommon. When they coexist, the use of levodopa may relieve both disorders. Disturbing swings of blood pressure have been reported in patients under treatment with levodopa when given a general anesthetic. In the Shy–Drager syndrome, orthostatic hypotension is associated with features of Parkinsonism. This disorder is characterized by mild features of parkinsonism, mild dementia, a tendency to sudden falls, impairment of conjugate eye movements—particularly vertical gaze—and nuchal rigidity. From a study of drug-induced parkinsonism described in the chapter, it was observed that reserpine might induce a parkinsonian state led to important work on amines in the nervous system. Most of the drugs that produce this effect act by interfering with dopamine. Provided that the nature of the condition is recognized, it can be relieved by reducing the dose of the drug responsible." @default.
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- W28608146 date "1985-01-01" @default.
- W28608146 modified "2023-10-16" @default.
- W28608146 title "Parkinsonism and involuntary movement" @default.
- W28608146 doi "https://doi.org/10.1016/b978-0-407-00310-1.50012-9" @default.
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