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• W2862719076 endingPage "1649" @default.
• W2862719076 startingPage "1649" @default.
• W2862719076 abstract "The O-linked β-N-acetylglucosamine (O-GlcNAc) modification is an abundant post-translational modification in eukaryotic cells, which plays a fundamental role in the activity of many cells and is associated with pathologies like type II diabetes, Alzheimer’s disease or some cancers. However, the precise connexion between O-GlcNAc-modified proteins and their function in cells is largely undefined for most cases. Confocal microscopy is a powerful and effective tool for in-cell elucidation of the function of biological molecules. Chemical labeling of non-ultraviolet or non-fluorescent carbohydrates with fluorescent tag is an essential step that makes intra-cellular microscopic inspection possible. Here we report a strategy based on the 1,3-dipolar cycloaddition, called click chemistry, between unnatural N-acetylglucosamine (GlcNAc) analogues Ac₄GlcNAc (substituted with an azido group) and the corresponding fluorescent tag Ru(bpy)₂(Phen-alkyne)Cl₂ (4) to synthesize the fluorescent dye Ru(bpy)₂(Phen-Ac₄GlcNAc)Cl₂ (5) under mild and neutral reaction conditions. Moreover, 5 showed good stability, desirable fluorescence characteristics, and exhibited rather low levels of cytotoxicity against sensitive MCF-7 cells. Additionally, we have achieved successful fluorescent imaging of 5 transported in living MCF-7 cells. Cell images displayed that proteins are potentially labelled with 5 in the cytoplasm." @default.
• W2862719076 created "2018-07-19" @default.
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• W2862719076 date "2018-07-06" @default.
• W2862719076 modified "2023-09-28" @default.
• W2862719076 title "Synthesis of a Novel Fluorescent Ruthenium Complex with an Appended Ac4GlcNAc Moiety by Click Reaction" @default.
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• W2862719076 doi "https://doi.org/10.3390/molecules23071649" @default.
• W2862719076 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6100033" @default.
• W2862719076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29986387" @default.
• W2862719076 hasPublicationYear "2018" @default.
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