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- W286532211 abstract "Growth of bacteriophage T7 is inhibited by the antibiotic coumermycin A/sub 1/, an inhibitor of the Escherichia coli DNA gyrase. Since growth of the phage is insensitive to the antibiotic in strains containing a coumermycin-resistent DNA gyrase, this enzyme appears to be required for phage growth. We have investigated the effect of coumermycin on the kinetics of DNA, RNA, and protein synthesis during T7 infection. DNA synthesis is completely inhibited by the antibiotic. In addition, coumermycin significantly inhibits transcription of late but not early genes. Thus, E. coli DNA gyrase may play an important role in transcription as well as in replication of T7 DNA." @default.
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- W286532211 date "1979-02-01" @default.
- W286532211 modified "2023-09-27" @default.
- W286532211 title "Involvement of DNA gyrase in replication and transcription of bacteriophage T7 DNA. [Uv radiation, Escherichia coli]" @default.
- W286532211 hasPublicationYear "1979" @default.
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