Matches in SemOpenAlex for { <https://semopenalex.org/work/W286616131> ?p ?o ?g. }
Showing items 1 to 72 of
72
with 100 items per page.
- W286616131 endingPage "205" @default.
- W286616131 startingPage "185" @default.
- W286616131 abstract "We studied the therapeutic effects of continuously infused N-acetylcysteine, an O2 radical scavenger (N, n = 6), and terbutaline, a beta 2-agonist (T, n = 6), versus dextrose (controls C, N = 6) on hemodynamics and regional albumin extravasation in porcine septic shock. After instrumentation, injection of 99mTc-labeled red blood cells, and baseline measurements, pigs received a 90 min infusion of 11 +/- 9 X 10(8).kg-1 live Escherichia coli bacteria. Thereafter, therapy was started, and 131I human serum albumin was injected. Images were obtained hourly using a gammacamera and a computer until 5 hours after baseline. Regions of interest were drawn in the 99mTc images, yielding regional 131I/99mTc radioactivity ratios, with blood samples as reference. From these ratios, an albumin leak index, a rate constant of transvascular albumin transport, was calculated. Control pigs developed pulmonary hypertension, arterial hypotension, hemoconcentration, and lactic acidemia. In spite of tachycardia and unchanged filling pressures, cardiac output fell. In arterial blood, white cell count, PO2, albumin level, and colloid osmotic pressure fell. The albumin leak index (X10(-3).min-1) measured 1.56 +/- 0.59 over the lungs and 2.87 +/- 1.19 over the abdomen in C (P less than .05 vs. lung), confirming previously found increased albumin flux in both lung and abdomen, the latter exceeding the former. Neither N nor T significantly affected hemodynamic and biochemical changes. The drugs neither decreased the regional albumin leak index nor attenuated the formation of albumin-rich ascites found at autopsy. However, the lung albumin index obtained at autopsy was significantly reduced with N (P less than .01 vs. C), at similar gravimetrically determined extravascular lung water (EVLW). EVLW positively correlated with pulmonary albumin extravasation in C (rs = 0.94, P less than .05) and T (rs = 0.89, P = .05) but not in N (rs = -0.37, n.s.). We conclude that neither N nor T treatment beneficially influences the course of septic shock in pigs. Although neither drug combats noninvasively assessed regional microvascular albumin leakage and formation of albumin-rich ascites, N may ameliorate increased pulmonary microvascular permeability as judged from post mortem data." @default.
- W286616131 created "2016-06-24" @default.
- W286616131 creator A5012703449 @default.
- W286616131 creator A5014615355 @default.
- W286616131 creator A5016328305 @default.
- W286616131 creator A5047537688 @default.
- W286616131 creator A5087396120 @default.
- W286616131 date "1990-03-01" @default.
- W286616131 modified "2023-09-26" @default.
- W286616131 title "Effects of N-acetylcysteine and terbutaline treatment on hemodynamics and regional albumin extravasation in porcine septic shock." @default.
- W286616131 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2178796" @default.
- W286616131 hasPublicationYear "1990" @default.
- W286616131 type Work @default.
- W286616131 sameAs 286616131 @default.
- W286616131 citedByCount "9" @default.
- W286616131 crossrefType "journal-article" @default.
- W286616131 hasAuthorship W286616131A5012703449 @default.
- W286616131 hasAuthorship W286616131A5014615355 @default.
- W286616131 hasAuthorship W286616131A5016328305 @default.
- W286616131 hasAuthorship W286616131A5047537688 @default.
- W286616131 hasAuthorship W286616131A5087396120 @default.
- W286616131 hasConcept C126322002 @default.
- W286616131 hasConcept C134018914 @default.
- W286616131 hasConcept C142724271 @default.
- W286616131 hasConcept C165616093 @default.
- W286616131 hasConcept C178853913 @default.
- W286616131 hasConcept C2776125364 @default.
- W286616131 hasConcept C2776452961 @default.
- W286616131 hasConcept C2777628635 @default.
- W286616131 hasConcept C2777953023 @default.
- W286616131 hasConcept C2778384902 @default.
- W286616131 hasConcept C2779540182 @default.
- W286616131 hasConcept C2781300812 @default.
- W286616131 hasConcept C42219234 @default.
- W286616131 hasConcept C71924100 @default.
- W286616131 hasConcept C84393581 @default.
- W286616131 hasConceptScore W286616131C126322002 @default.
- W286616131 hasConceptScore W286616131C134018914 @default.
- W286616131 hasConceptScore W286616131C142724271 @default.
- W286616131 hasConceptScore W286616131C165616093 @default.
- W286616131 hasConceptScore W286616131C178853913 @default.
- W286616131 hasConceptScore W286616131C2776125364 @default.
- W286616131 hasConceptScore W286616131C2776452961 @default.
- W286616131 hasConceptScore W286616131C2777628635 @default.
- W286616131 hasConceptScore W286616131C2777953023 @default.
- W286616131 hasConceptScore W286616131C2778384902 @default.
- W286616131 hasConceptScore W286616131C2779540182 @default.
- W286616131 hasConceptScore W286616131C2781300812 @default.
- W286616131 hasConceptScore W286616131C42219234 @default.
- W286616131 hasConceptScore W286616131C71924100 @default.
- W286616131 hasConceptScore W286616131C84393581 @default.
- W286616131 hasIssue "3" @default.
- W286616131 hasLocation W2866161311 @default.
- W286616131 hasOpenAccess W286616131 @default.
- W286616131 hasPrimaryLocation W2866161311 @default.
- W286616131 hasRelatedWork W113384533 @default.
- W286616131 hasRelatedWork W2017677715 @default.
- W286616131 hasRelatedWork W2022177906 @default.
- W286616131 hasRelatedWork W2028209775 @default.
- W286616131 hasRelatedWork W2074088163 @default.
- W286616131 hasRelatedWork W2349687057 @default.
- W286616131 hasRelatedWork W2361462485 @default.
- W286616131 hasRelatedWork W2375342862 @default.
- W286616131 hasRelatedWork W2416917069 @default.
- W286616131 hasRelatedWork W286616131 @default.
- W286616131 hasVolume "30" @default.
- W286616131 isParatext "false" @default.
- W286616131 isRetracted "false" @default.
- W286616131 magId "286616131" @default.
- W286616131 workType "article" @default.