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• W2866394555 abstract "Abstract The heart and its cellular components are profoundly altered by missions to space and injury on Earth. Further research, however, is needed to characterize and address the molecular substrates of such changes. For this reason, neonatal and adult human cardiovascular progenitor cells (CPCs) were cultured aboard the International Space Station. Upon return to Earth, we measured changes in the expression of microRNAs and of genes related to mechanotransduction, cardiogenesis, cell cycling, DNA repair, and paracrine signaling. We additionally assessed endothelial-like tube formation, cell cycling, and migratory capacity of CPCs. Changes in microRNA expression were predicted to target extracellular matrix interactions and Hippo signaling in both neonatal and adult CPCs. Genes related to mechanotransduction ( YAP1, RHOA ) were downregulated, while the expression of cytoskeletal genes ( VIM , NES , DES , LMNB2 , LMNA ), non-canonical Wnt ligands ( WNT5A , WNT9A ), and Wnt/calcium signaling molecules ( PLCG1 , PRKCA ) was significantly elevated in neonatal CPCs. Increased mesendodermal gene expression along with decreased expression of mesodermal derivative markers ( TNNT2 , VWF , and RUNX2 ), reduced readiness to form endothelial-like tubes, and elevated expression of Bmp and Tbx genes, were observed in neonatal CPCs. Both neonatal and adult CPCs exhibited increased expression of DNA repair genes and paracrine factors, which was supported by enhanced migration. While spaceflight affects cytoskeletal organization and migration in neonatal and adult CPCs, only neonatal CPCs experienced increased expression of early developmental markers and an enhanced proliferative potential. Efforts to recapitulate the effects of spaceflight on Earth by regulating processes described herein may be a promising avenue for cardiac repair." @default.
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• W2866394555 date "2018-07-26" @default.
• W2866394555 modified "2023-10-16" @default.
• W2866394555 title "Cardiovascular progenitor cells cultured aboard the International Space Station exhibit altered developmental and functional properties" @default.
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• W2866394555 doi "https://doi.org/10.1038/s41526-018-0048-x" @default.
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