Matches in SemOpenAlex for { <https://semopenalex.org/work/W2867451337> ?p ?o ?g. }
- W2867451337 endingPage "e1007487" @default.
- W2867451337 startingPage "e1007487" @default.
- W2867451337 abstract "Altered glucose and lipid metabolism fuel cystic growth in polycystic kidneys, but the cause of these perturbations is unclear. Renal cysts also associate with mutations in Bicaudal C1 (Bicc1) or in its self-polymerizing sterile alpha motif (SAM). Here, we found that Bicc1 maintains normoglycemia and the expression of the gluconeogenic enzymes FBP1 and PEPCK in kidneys. A proteomic screen revealed that Bicc1 interacts with the C-Terminal to Lis-Homology domain (CTLH) complex. Since the orthologous Gid complex in S. cerevisae targets FBP1 and PEPCK for degradation, we mapped the topology among CTLH subunits and found that SAM-mediated binding controls Bicc1 protein levels, whereas Bicc1 inhibited the accumulation of several CTLH subunits. Under the conditions analyzed, Bicc1 increased FBP1 protein levels independently of the CTLH complex. Besides linking Bicc1 to cell metabolism, our findings reveal new layers of complexity in the regulation of renal gluconeogenesis compared to lower eukaryotes." @default.
- W2867451337 created "2018-07-19" @default.
- W2867451337 creator A5010009278 @default.
- W2867451337 creator A5054495304 @default.
- W2867451337 creator A5061985260 @default.
- W2867451337 creator A5064346931 @default.
- W2867451337 creator A5084792448 @default.
- W2867451337 date "2018-07-11" @default.
- W2867451337 modified "2023-10-17" @default.
- W2867451337 title "Role of Bicaudal C1 in renal gluconeogenesis and its novel interaction with the CTLH complex" @default.
- W2867451337 cites W116831975 @default.
- W2867451337 cites W1516616567 @default.
- W2867451337 cites W1919142731 @default.
- W2867451337 cites W1966289658 @default.
- W2867451337 cites W1973086328 @default.
- W2867451337 cites W1978494513 @default.
- W2867451337 cites W1978569216 @default.
- W2867451337 cites W1980924412 @default.
- W2867451337 cites W1982868094 @default.
- W2867451337 cites W1983711788 @default.
- W2867451337 cites W1985621273 @default.
- W2867451337 cites W1993193415 @default.
- W2867451337 cites W1993802679 @default.
- W2867451337 cites W1995023368 @default.
- W2867451337 cites W1997170902 @default.
- W2867451337 cites W2019315324 @default.
- W2867451337 cites W2020040718 @default.
- W2867451337 cites W2020495961 @default.
- W2867451337 cites W2023843317 @default.
- W2867451337 cites W2027931280 @default.
- W2867451337 cites W2030573365 @default.
- W2867451337 cites W2030951801 @default.
- W2867451337 cites W2032735361 @default.
- W2867451337 cites W2038591876 @default.
- W2867451337 cites W2042265513 @default.
- W2867451337 cites W2048754647 @default.
- W2867451337 cites W2056196374 @default.
- W2867451337 cites W2057139407 @default.
- W2867451337 cites W2058318950 @default.
- W2867451337 cites W2063878753 @default.
- W2867451337 cites W2068068551 @default.
- W2867451337 cites W2068803684 @default.
- W2867451337 cites W2069663698 @default.
- W2867451337 cites W2078678532 @default.
- W2867451337 cites W2088322038 @default.
- W2867451337 cites W2088545470 @default.
- W2867451337 cites W2089327117 @default.
- W2867451337 cites W2096330480 @default.
- W2867451337 cites W2098206628 @default.
- W2867451337 cites W2103690924 @default.
- W2867451337 cites W2107290783 @default.
- W2867451337 cites W2107818820 @default.
- W2867451337 cites W2114230673 @default.
- W2867451337 cites W2114767334 @default.
- W2867451337 cites W2119786796 @default.
- W2867451337 cites W2120388928 @default.
- W2867451337 cites W2134965931 @default.
- W2867451337 cites W2140073418 @default.
- W2867451337 cites W2141331673 @default.
- W2867451337 cites W2151527573 @default.
- W2867451337 cites W2151563319 @default.
- W2867451337 cites W2161701113 @default.
- W2867451337 cites W2167353494 @default.
- W2867451337 cites W2167380395 @default.
- W2867451337 cites W2169403426 @default.
- W2867451337 cites W2257686840 @default.
- W2867451337 cites W2290305064 @default.
- W2867451337 cites W2328128893 @default.
- W2867451337 cites W2582862246 @default.
- W2867451337 cites W2605060594 @default.
- W2867451337 cites W2605925078 @default.
- W2867451337 cites W2606253210 @default.
- W2867451337 cites W2725958576 @default.
- W2867451337 cites W2739084021 @default.
- W2867451337 cites W2780973115 @default.
- W2867451337 cites W2781654316 @default.
- W2867451337 cites W2805891476 @default.
- W2867451337 cites W632778377 @default.
- W2867451337 cites W870598377 @default.
- W2867451337 doi "https://doi.org/10.1371/journal.pgen.1007487" @default.
- W2867451337 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6056059" @default.
- W2867451337 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29995892" @default.
- W2867451337 hasPublicationYear "2018" @default.
- W2867451337 type Work @default.
- W2867451337 sameAs 2867451337 @default.
- W2867451337 citedByCount "23" @default.
- W2867451337 countsByYear W28674513372019 @default.
- W2867451337 countsByYear W28674513372020 @default.
- W2867451337 countsByYear W28674513372021 @default.
- W2867451337 countsByYear W28674513372022 @default.
- W2867451337 countsByYear W28674513372023 @default.
- W2867451337 crossrefType "journal-article" @default.
- W2867451337 hasAuthorship W2867451337A5010009278 @default.
- W2867451337 hasAuthorship W2867451337A5054495304 @default.
- W2867451337 hasAuthorship W2867451337A5061985260 @default.
- W2867451337 hasAuthorship W2867451337A5064346931 @default.
- W2867451337 hasAuthorship W2867451337A5084792448 @default.
- W2867451337 hasBestOaLocation W28674513371 @default.