Matches in SemOpenAlex for { <https://semopenalex.org/work/W2868404562> ?p ?o ?g. }
- W2868404562 endingPage "14345" @default.
- W2868404562 startingPage "14341" @default.
- W2868404562 abstract "Here it is shown that glycosaminoglycans (GAGs) with high molecular weight can be grafted via their reducing end on hyperbranched synthetic cores by oxime condensation without the need of any previous functionalisation of the polysaccharide. The versatility of this reaction is demonstrated by the use of hyaluronan, chondroitin sulfate and heparin with up to 60 sugar units. The isothermal calorimetry analysis demonstrated that the generated star-like glycopolymers have superior bioactivity. Moreover, when mixed with positively charged proteins (e.g., fibroblast growth factor-2, FGF-2) they form microfiber structures instead of the spherical nanocomplexes described for linear GAGs. The results suggest that the described star-like GAG are closer mimics of the proteoglycans at the structural and functional level and therefore have huge potential in the development of tissue engineering platforms and therapeutics by modulating the activity and presentation of various proteins such as growth factors." @default.
- W2868404562 created "2018-07-19" @default.
- W2868404562 creator A5004018442 @default.
- W2868404562 creator A5058320346 @default.
- W2868404562 creator A5075034238 @default.
- W2868404562 creator A5080219954 @default.
- W2868404562 creator A5081499203 @default.
- W2868404562 date "2018-09-04" @default.
- W2868404562 modified "2023-10-17" @default.
- W2868404562 title "Star-Like Glycosaminoglycans with Superior Bioactivity Assemble with Proteins into Microfibers" @default.
- W2868404562 cites W1964857509 @default.
- W2868404562 cites W1965294891 @default.
- W2868404562 cites W1973250282 @default.
- W2868404562 cites W1980487080 @default.
- W2868404562 cites W1982423863 @default.
- W2868404562 cites W1982814991 @default.
- W2868404562 cites W1983862056 @default.
- W2868404562 cites W1994543965 @default.
- W2868404562 cites W1995992975 @default.
- W2868404562 cites W2001492234 @default.
- W2868404562 cites W2010621614 @default.
- W2868404562 cites W2012374953 @default.
- W2868404562 cites W2019030900 @default.
- W2868404562 cites W2019085666 @default.
- W2868404562 cites W2020737596 @default.
- W2868404562 cites W2021806900 @default.
- W2868404562 cites W2026873019 @default.
- W2868404562 cites W2030119158 @default.
- W2868404562 cites W2037940280 @default.
- W2868404562 cites W2039165135 @default.
- W2868404562 cites W2050082215 @default.
- W2868404562 cites W2053399221 @default.
- W2868404562 cites W2054587080 @default.
- W2868404562 cites W2055574789 @default.
- W2868404562 cites W2059529313 @default.
- W2868404562 cites W2061063196 @default.
- W2868404562 cites W2065088375 @default.
- W2868404562 cites W2067411415 @default.
- W2868404562 cites W2074763334 @default.
- W2868404562 cites W2081714233 @default.
- W2868404562 cites W2086587366 @default.
- W2868404562 cites W2088158211 @default.
- W2868404562 cites W2092751827 @default.
- W2868404562 cites W2101032230 @default.
- W2868404562 cites W2110798417 @default.
- W2868404562 cites W2112727895 @default.
- W2868404562 cites W2119900313 @default.
- W2868404562 cites W2144496575 @default.
- W2868404562 cites W2145258357 @default.
- W2868404562 cites W2473775182 @default.
- W2868404562 cites W2514574167 @default.
- W2868404562 cites W2803563565 @default.
- W2868404562 cites W4210954513 @default.
- W2868404562 cites W4242773223 @default.
- W2868404562 doi "https://doi.org/10.1002/chem.201802243" @default.
- W2868404562 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29974983" @default.
- W2868404562 hasPublicationYear "2018" @default.
- W2868404562 type Work @default.
- W2868404562 sameAs 2868404562 @default.
- W2868404562 citedByCount "6" @default.
- W2868404562 countsByYear W28684045622019 @default.
- W2868404562 countsByYear W28684045622020 @default.
- W2868404562 countsByYear W28684045622021 @default.
- W2868404562 countsByYear W28684045622022 @default.
- W2868404562 crossrefType "journal-article" @default.
- W2868404562 hasAuthorship W2868404562A5004018442 @default.
- W2868404562 hasAuthorship W2868404562A5058320346 @default.
- W2868404562 hasAuthorship W2868404562A5075034238 @default.
- W2868404562 hasAuthorship W2868404562A5080219954 @default.
- W2868404562 hasAuthorship W2868404562A5081499203 @default.
- W2868404562 hasBestOaLocation W28684045622 @default.
- W2868404562 hasConcept C12554922 @default.
- W2868404562 hasConcept C12820456 @default.
- W2868404562 hasConcept C136229726 @default.
- W2868404562 hasConcept C153074725 @default.
- W2868404562 hasConcept C170493617 @default.
- W2868404562 hasConcept C178790620 @default.
- W2868404562 hasConcept C185592680 @default.
- W2868404562 hasConcept C2776735749 @default.
- W2868404562 hasConcept C2779553658 @default.
- W2868404562 hasConcept C49892992 @default.
- W2868404562 hasConcept C55493867 @default.
- W2868404562 hasConcept C71924100 @default.
- W2868404562 hasConcept C74373430 @default.
- W2868404562 hasConcept C86803240 @default.
- W2868404562 hasConceptScore W2868404562C12554922 @default.
- W2868404562 hasConceptScore W2868404562C12820456 @default.
- W2868404562 hasConceptScore W2868404562C136229726 @default.
- W2868404562 hasConceptScore W2868404562C153074725 @default.
- W2868404562 hasConceptScore W2868404562C170493617 @default.
- W2868404562 hasConceptScore W2868404562C178790620 @default.
- W2868404562 hasConceptScore W2868404562C185592680 @default.
- W2868404562 hasConceptScore W2868404562C2776735749 @default.
- W2868404562 hasConceptScore W2868404562C2779553658 @default.
- W2868404562 hasConceptScore W2868404562C49892992 @default.
- W2868404562 hasConceptScore W2868404562C55493867 @default.
- W2868404562 hasConceptScore W2868404562C71924100 @default.
- W2868404562 hasConceptScore W2868404562C74373430 @default.