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- W2868459684 abstract "Obesity and hyperlipidemia are a major problem in the world. Pluchea indica (L.) Less. tea (PIT) is a beverage that has various indications. This study focused on the effect of the PIT on inhibiting adipogenesis of 3T3-L1 cells and pancreatic lipase enzyme activity. The viability of 3T3-L1 cells was not significantly decreased after exposure to 200 to 1000 μ g mL −1 PIT compared to controls (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mi>p</mml:mi><mml:mo>></mml:mo><mml:mn fontstyle=italic>0.05</mml:mn></mml:math>). The PIT at 750 to 1000 μ g mL −1 exhibited a significantly reduced lipid accumulation compared to the control (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.05</mml:mn></mml:math>). The inhibitory effects of the PIT at 250 to 1000 μ g mL −1 on lipase activity were significantly increased compared to control (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.05</mml:mn></mml:math>). The FTIR results showed that the integrated areas of lipids, proteins, nucleic acids, glycogen, and carbohydrates of the PIT-treated 3T3-L1 adipocytes were significantly lower than the untreated 3T3-L1 adipocytes (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.05</mml:mn></mml:math>). These findings may indicate that the PIT is not only capable of inhibiting lipids and carbohydrate accumulation in adipocytes but also has a potential to inhibit pancreatic lipase activity. So, the PIT may be further developed to the novel lipid-lowering herbal supplement for the management of overweight or obesity." @default.
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- W2868459684 date "2018-07-12" @default.
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- W2868459684 title "The Effect of<i> Pluchea indica</i> (L.) Less. Tea on Adipogenesis in 3T3-L1 Adipocytes and Lipase Activity" @default.
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- W2868459684 doi "https://doi.org/10.1155/2018/4108787" @default.
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