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- W2868753417 abstract "This chapter addresses a series of focused clinical questions of metastatic castration-resistant prostate cancer (mCRPC) that are addressed in a systematic fashion, including a comprehensive literature search, a rating of the quality of evidence, and an assessment of ratio of benefit and harm of a given treatment option. The clinical questions are: In patients with hormone-sensitive prostate cancer, how does up-front chemotherapy in conjunction with systemic androgen deprivation therapy (ADT) compare with systemic ADT alone? and In patients with hormone-sensitive prostate cancer, how does up-front abiraterone (AA) plus prednisone in conjunction with systemic ADT compare with ADT alone? The remaining questions are: In patients with mCRPC without visceral or symptomatic bone metastases, is there a benefit in overall survival when using cytotoxic chemotherapy? and In patients with mCRPC, how do newer advanced hormonal agents targeting the androgen-signaling pathway compare with regard to patient survival?" @default.
- W2868753417 created "2018-07-19" @default.
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- W2868753417 date "2018-07-06" @default.
- W2868753417 modified "2023-10-12" @default.
- W2868753417 title "Management of metastatic prostate cancer" @default.
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- W2868753417 doi "https://doi.org/10.1002/9781119129875.ch28" @default.
- W2868753417 hasPublicationYear "2018" @default.
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