Matches in SemOpenAlex for { <https://semopenalex.org/work/W2869728636> ?p ?o ?g. }
- W2869728636 endingPage "84" @default.
- W2869728636 startingPage "75" @default.
- W2869728636 abstract "Pygo2 as a Wnt signaling pathway component has been detected in multiple cancer types. In this study, we identified Pygo2 expression features by immunohistochemistry in 73 central nervous system tumor specimens, in comparison with 14 normal brain tissues and surrounding non-tumorous tissues of tumor. Our study indicated that 59% of the patient tumor specimens exhibited positive Pygo2-staining and increases intensity with the grade of malignancy, especially for WHO grade III and IV gliomas, was observed high level expression, compared with normal brain tissues. Five out of nine WHO grade III anaplastic astrocytomas and seven out of nine WHO grade IV glioblastomas showed Pygo2-positive staining. The analysis of Pygo2 gene expression by quantitative real-time PCR of additional ten fresh patient samples yielded similar results. Further studies performed with stable cell lines in vitro demonstrated that Pygo2 render cells higher proliferation rate, migration and anchorage-independent colony-forming ability in soft agar. Taken together, our studies suggest an important role of Pygo2 in brain tumor progression." @default.
- W2869728636 created "2018-07-19" @default.
- W2869728636 creator A5026303060 @default.
- W2869728636 creator A5037830618 @default.
- W2869728636 creator A5039983510 @default.
- W2869728636 creator A5041558510 @default.
- W2869728636 creator A5053219311 @default.
- W2869728636 creator A5053330465 @default.
- W2869728636 creator A5054694585 @default.
- W2869728636 creator A5083652271 @default.
- W2869728636 date "2018-07-05" @default.
- W2869728636 modified "2023-09-26" @default.
- W2869728636 title "Immunohistochemistry analysis of Pygo2 expression in central nervous system tumors" @default.
- W2869728636 cites W1500827124 @default.
- W2869728636 cites W1516532472 @default.
- W2869728636 cites W164445532 @default.
- W2869728636 cites W1988702611 @default.
- W2869728636 cites W1994029539 @default.
- W2869728636 cites W1999529607 @default.
- W2869728636 cites W2002659820 @default.
- W2869728636 cites W2003546293 @default.
- W2869728636 cites W2015288103 @default.
- W2869728636 cites W2021483451 @default.
- W2869728636 cites W2025707029 @default.
- W2869728636 cites W2030115768 @default.
- W2869728636 cites W2033031243 @default.
- W2869728636 cites W2039858705 @default.
- W2869728636 cites W2045917414 @default.
- W2869728636 cites W2051041196 @default.
- W2869728636 cites W2055475004 @default.
- W2869728636 cites W2060655996 @default.
- W2869728636 cites W2062723225 @default.
- W2869728636 cites W2078015118 @default.
- W2869728636 cites W2081285815 @default.
- W2869728636 cites W2098341282 @default.
- W2869728636 cites W2106733257 @default.
- W2869728636 cites W2136183527 @default.
- W2869728636 cites W2139739677 @default.
- W2869728636 cites W2143098252 @default.
- W2869728636 cites W2169073587 @default.
- W2869728636 cites W2174005192 @default.
- W2869728636 cites W2295455218 @default.
- W2869728636 cites W2754595731 @default.
- W2869728636 cites W2763755167 @default.
- W2869728636 cites W3189400240 @default.
- W2869728636 cites W4244344354 @default.
- W2869728636 doi "https://doi.org/10.1007/s12079-018-0476-0" @default.
- W2869728636 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6381371" @default.
- W2869728636 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/29978348" @default.
- W2869728636 hasPublicationYear "2018" @default.
- W2869728636 type Work @default.
- W2869728636 sameAs 2869728636 @default.
- W2869728636 citedByCount "0" @default.
- W2869728636 crossrefType "journal-article" @default.
- W2869728636 hasAuthorship W2869728636A5026303060 @default.
- W2869728636 hasAuthorship W2869728636A5037830618 @default.
- W2869728636 hasAuthorship W2869728636A5039983510 @default.
- W2869728636 hasAuthorship W2869728636A5041558510 @default.
- W2869728636 hasAuthorship W2869728636A5053219311 @default.
- W2869728636 hasAuthorship W2869728636A5053330465 @default.
- W2869728636 hasAuthorship W2869728636A5054694585 @default.
- W2869728636 hasAuthorship W2869728636A5083652271 @default.
- W2869728636 hasBestOaLocation W28697286362 @default.
- W2869728636 hasConcept C121608353 @default.
- W2869728636 hasConcept C126322002 @default.
- W2869728636 hasConcept C137620995 @default.
- W2869728636 hasConcept C142724271 @default.
- W2869728636 hasConcept C169760540 @default.
- W2869728636 hasConcept C204232928 @default.
- W2869728636 hasConcept C2778227246 @default.
- W2869728636 hasConcept C2779399171 @default.
- W2869728636 hasConcept C502942594 @default.
- W2869728636 hasConcept C529278444 @default.
- W2869728636 hasConcept C55493867 @default.
- W2869728636 hasConcept C62478195 @default.
- W2869728636 hasConcept C71924100 @default.
- W2869728636 hasConcept C86803240 @default.
- W2869728636 hasConceptScore W2869728636C121608353 @default.
- W2869728636 hasConceptScore W2869728636C126322002 @default.
- W2869728636 hasConceptScore W2869728636C137620995 @default.
- W2869728636 hasConceptScore W2869728636C142724271 @default.
- W2869728636 hasConceptScore W2869728636C169760540 @default.
- W2869728636 hasConceptScore W2869728636C204232928 @default.
- W2869728636 hasConceptScore W2869728636C2778227246 @default.
- W2869728636 hasConceptScore W2869728636C2779399171 @default.
- W2869728636 hasConceptScore W2869728636C502942594 @default.
- W2869728636 hasConceptScore W2869728636C529278444 @default.
- W2869728636 hasConceptScore W2869728636C55493867 @default.
- W2869728636 hasConceptScore W2869728636C62478195 @default.
- W2869728636 hasConceptScore W2869728636C71924100 @default.
- W2869728636 hasConceptScore W2869728636C86803240 @default.
- W2869728636 hasFunder F4320321001 @default.
- W2869728636 hasIssue "1" @default.
- W2869728636 hasLocation W28697286361 @default.
- W2869728636 hasLocation W28697286362 @default.
- W2869728636 hasLocation W28697286363 @default.
- W2869728636 hasLocation W28697286364 @default.
- W2869728636 hasOpenAccess W2869728636 @default.