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- W286997429 abstract "Recently, chemical cross-linking of proteins has gained renewed interest with respect to elucidation of the tertiary structure of proteins or protein complexes /1-5/. Towards this end we have used the homobifunctional cross-linking agent EDC (1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide hydrochloride) to map contacts in the RanGAP/Ran-complex consisting of two molecules of RanGAP and one molecule of Ran. Ran is a small GTPase of the Ras superfamily which shuttles between the nucleoplasm and the cytoplasm and which is an essential factor of most nucleoplasmic transport events across the nuclear pore complex. Ran cycles between a GTP and a GDP bound conformation and this cycle provides the driving force for directionality in nuclear import and export. Efficient Ran cycling requires the activity of two accessory proteins, a nuclear GTP for GDP exchange factor (RanGEF) and a cytoplasmic GTPase activating protein (RanGAP). We had recently shown that a complex of two RanGAPs and GMPPNP-bound Ran can be stabilised by cross-linking with EDC /6, 7/." @default.
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- W286997429 date "2001-06-01" @default.
- W286997429 modified "2023-09-27" @default.
- W286997429 title "Tertiary Structure Analysis of the Rangap/Ran-Complex Using Chemical Cross-Linking: Model for Software Developments in Protein Sequencing" @default.
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