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- W2870266213 abstract "We apply optimal control theory to a model of interactions between cancer cells, CD4+ T cells,cytokines and host cells to devise best immunotherapies for treating cancer. The CD4+ T cells cannotkill cancer cells directly but use the cytokines produced to suppress tumor growth. The immunotherapyimplemented is modeled as a control agent and it can be either transferring of CD4+ T cells, cytokines orboth. We establish existence and uniqueness of the optimal control. The optimal treatment strategy isthen solved numerically under different scenarios. Our numerical results provide best protocols in termsof strengths and timing of the treatments." @default.
- W2870266213 created "2018-07-19" @default.
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- W2870266213 date "2018-01-01" @default.
- W2870266213 modified "2023-09-23" @default.
- W2870266213 title "Optimal Treatments in Cancer Immunotherapy Involving CD4+ T Cells" @default.
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