FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2870291935> ?p ?o ?g. }

• W2870291935 endingPage "652" @default.
• W2870291935 startingPage "645" @default.
• W2870291935 abstract "In vitro bioassays are increasingly applied for water quality monitoring, with assays indicative of adaptive stress responses commonly included in test batteries. The NF-κB assay is responsive to surface water and wastewater extracts, but the causative compounds are unknown and micropollutants typically found in water do not activate the NF-κB assay. The current study aimed to investigate if co-extracted organic matter and/or endotoxins could cause the NF-κB response in surface water extracts. The effect of model bacterial lipopolysaccharides (LPS) and dissolved organic carbon (DOC) was evaluated in the NF-κB assay both before and after solid-phase extraction (SPE), with 7% effect recovery for LPS and between 7 and 52% effect recovery for DOC observed. The NF-κB response, endotoxin activity, micropollutant concentration and total organic carbon concentration was measured in four surface water extracts. All water extracts showed a response in the NF-κB assay, but the detected micropollutants could not explain the effect. Comparison of predicted bioanalytical equivalent concentrations based on micropollutant, DOC and endotoxin concentrations in surface water with experimental bioanalytical equivalent concentrations suggest that co-extracted endotoxins are the most important drivers of the observed effect, with DOC only having a minor contribution. While in vitro bioassays typically detect mixtures of organic micropollutants, the current study shows that the NF-κB assay can integrate the effects of co-extracted endotoxins. Given that endotoxins can pose a risk for human health, the NF-κB assay is a valuable inclusion in bioanalytical test batteries used for water quality monitoring." @default.
• W2870291935 created "2018-07-19" @default.
• W2870291935 creator A5019740923 @default.
• W2870291935 creator A5063477493 @default.
• W2870291935 creator A5074992112 @default.
• W2870291935 date "2018-11-01" @default.
• W2870291935 modified "2023-09-24" @default.
• W2870291935 title "What is driving the NF-κB response in environmental water extracts?" @default.
• W2870291935 cites W1490349033 @default.
• W2870291935 cites W1972514204 @default.
• W2870291935 cites W1973965044 @default.
• W2870291935 cites W1976226148 @default.
• W2870291935 cites W1977348907 @default.
• W2870291935 cites W1994701384 @default.
• W2870291935 cites W1995625202 @default.
• W2870291935 cites W1999177172 @default.
• W2870291935 cites W2003070275 @default.
• W2870291935 cites W2029277701 @default.
• W2870291935 cites W2039023381 @default.
• W2870291935 cites W2039696688 @default.
• W2870291935 cites W2049922512 @default.
• W2870291935 cites W2061903251 @default.
• W2870291935 cites W2062423625 @default.
• W2870291935 cites W2068878609 @default.
• W2870291935 cites W2069586371 @default.
• W2870291935 cites W2072323030 @default.
• W2870291935 cites W2072846263 @default.
• W2870291935 cites W2081161751 @default.
• W2870291935 cites W2086193195 @default.
• W2870291935 cites W2092937632 @default.
• W2870291935 cites W2119930860 @default.
• W2870291935 cites W2124343538 @default.
• W2870291935 cites W2133615159 @default.
• W2870291935 cites W2164610579 @default.
• W2870291935 cites W2201318643 @default.
• W2870291935 cites W2276405519 @default.
• W2870291935 cites W2344578960 @default.
• W2870291935 cites W2429732176 @default.
• W2870291935 cites W2504368687 @default.
• W2870291935 cites W2544738886 @default.
• W2870291935 cites W2555539164 @default.
• W2870291935 cites W2624992950 @default.
• W2870291935 cites W2731889197 @default.
• W2870291935 cites W2752890262 @default.
• W2870291935 cites W2765710644 @default.
• W2870291935 cites W2768724176 @default.
• W2870291935 cites W2781771346 @default.
• W2870291935 cites W2790092593 @default.
• W2870291935 cites W2793118582 @default.
• W2870291935 cites W2795672088 @default.
• W2870291935 cites W326423902 @default.
• W2870291935 cites W4238098195 @default.
• W2870291935 cites W785759744 @default.
• W2870291935 doi "https://doi.org/10.1016/j.chemosphere.2018.07.052" @default.
• W2870291935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/30031348" @default.
• W2870291935 hasPublicationYear "2018" @default.
• W2870291935 type Work @default.
• W2870291935 sameAs 2870291935 @default.
• W2870291935 citedByCount "7" @default.
• W2870291935 countsByYear W28702919352019 @default.
• W2870291935 countsByYear W28702919352020 @default.
• W2870291935 countsByYear W28702919352021 @default.
• W2870291935 countsByYear W28702919352022 @default.
• W2870291935 countsByYear W28702919352023 @default.
• W2870291935 crossrefType "journal-article" @default.
• W2870291935 hasAuthorship W2870291935A5019740923 @default.
• W2870291935 hasAuthorship W2870291935A5063477493 @default.
• W2870291935 hasAuthorship W2870291935A5074992112 @default.
• W2870291935 hasBestOaLocation W28702919352 @default.
• W2870291935 hasConcept C104488531 @default.
• W2870291935 hasConcept C107872376 @default.
• W2870291935 hasConcept C137535248 @default.
• W2870291935 hasConcept C185592680 @default.
• W2870291935 hasConcept C18903297 @default.
• W2870291935 hasConcept C2780797713 @default.
• W2870291935 hasConcept C36574619 @default.
• W2870291935 hasConcept C39432304 @default.
• W2870291935 hasConcept C43617362 @default.
• W2870291935 hasConcept C4725764 @default.
• W2870291935 hasConcept C54355233 @default.
• W2870291935 hasConcept C81426234 @default.
• W2870291935 hasConcept C8625798 @default.
• W2870291935 hasConcept C86803240 @default.
• W2870291935 hasConcept C87717796 @default.
• W2870291935 hasConceptScore W2870291935C104488531 @default.
• W2870291935 hasConceptScore W2870291935C107872376 @default.
• W2870291935 hasConceptScore W2870291935C137535248 @default.
• W2870291935 hasConceptScore W2870291935C185592680 @default.
• W2870291935 hasConceptScore W2870291935C18903297 @default.
• W2870291935 hasConceptScore W2870291935C2780797713 @default.
• W2870291935 hasConceptScore W2870291935C36574619 @default.
• W2870291935 hasConceptScore W2870291935C39432304 @default.
• W2870291935 hasConceptScore W2870291935C43617362 @default.
• W2870291935 hasConceptScore W2870291935C4725764 @default.
• W2870291935 hasConceptScore W2870291935C54355233 @default.
• W2870291935 hasConceptScore W2870291935C81426234 @default.
• W2870291935 hasConceptScore W2870291935C8625798 @default.
• W2870291935 hasConceptScore W2870291935C86803240 @default.

• next